Trichomonas vaginalis inhibition

Lloyd D, Kristensen (1985) Metronidazole inhibition of hydrogen production in vivo in drug-sensitive and resistant strains of Trichomonas vaginalis. J Gen Microbiol 131 849-853... 

Tachezy J, Sanchez LB, Muller M (2001) Mitochondrial type iron-sulfur cluster assembly in the amitochondriate eukaryotes Trichomonas vaginalis and Giardia intestinalis, as indicated by the phylogeny of IscS. Mol Biol Evol 18 1919-1928 Tadolini (1988) Polyamine inhibition of lipoperoxidation the influence of polyamines on iron oxidation in the presence of compounds mimicking phospholipid polar heads. Biochem J 249 33-36... 

Trichomonad flagellates seemed to be a good first choice. The human pathogen Trichomonas vaginalis and the cattle pathogen Tritrichomonas foetus were much-studied species available in bacterium-free cultures and were thus amenable to biochemical and cell fractionation studies, approaches extensively practiced by our group. The available physiological data showed that the respiration of these species was not of mitochondrial type, because it could not be inhibited with cyanide and other mitochondrial inhibitors. Furthermore no cytochromes were detected in these trichomonads (Ryley 1955). 

A few antimicrobials have useful activity across several of these groups. For example, metronidazole inhibits obligate anaerobic bacteria (such as Clostridium perfringetis) as well as some protozoa that rely on anaerobic metabolic pathways (such as Trichomonas vaginalis). 

Yarlett, N., Goldberg, B., Moharrami, M. A. and Bacchi, C. J. (1992) Inhibition of Trichomonas vaginalis ornithine decarboxylase by amino acid analogs. Biochem. Pharmacol. 44 243-250. 

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