Trichloromethane boiling point

Chloroform (trichloromethane, CHClj). Chloroform was first used as an anaesthetic in 1847 and its narcotic effects on the central nervous are well documented (ref. 4la). It has important applications as an intermediate in the chemical synthesis of a large number of industrial chemicals chlorofluorocarbons, dyes, drugs and pesticides. Its powerful solvent properties and low boiling point (6l°C) have made it a favorite for extractive and purification operations in preparing antibiotics, alkaloids, flavors and vitamins. 

The following table shows the boiling point, Tb, of benzene and trichloromethane, along with their enthalpies of vaporisation ... 

CH3C1 Chloromethane Boiling point — 24°C CH2CI2 Dichloromethane 40"C CHCI3 Trichloromethane 6FC CCI4 T etrachloromethane ITC... 

Tyrosol and other BPs have been extracted from spiked samples of alpechm by using liquid-liquid microextraction with ethyl acetate, which was preferred to ethyl ether, n-hexane, dichloromethane, and trichloromethane by virtue of its increased recoveries and low boiling point, which would faciUtate its removal [267]. 

Previous research in this project dealt mainly with soxhlet extraction in general and related work as purification of solvents and extracts, testing several solvents in terms of extraction power to PAH, stability at boiling point and selectivity. Previously used solvents were methanol, dichloro-methane, trichloromethane, tetrachloromethane, cyclohexane, benzene, toluene, all xylenes, mesitylene, tetralin, tetrahydrofuran and acetic acid. 

Method M2-A To a stirred appropriate dialkyl phosphonate (40 mmol) in tri-chloromethane (15 mL), an appropriate aldehyde (44 mmol) in trichloromethane (15 mL) was added at room temperature. The mixture was cooled to 8-10 °C, triethylamine (20 mmol) was added drop wise and then the mixmre was stirred at 20-70 °C for 2-3 h. The component with lower boiling point was evaporated in vacuo to give the corresponding cmde 1-hydroxyalkyIphosphonate. Purification by column chromatography on silica gel and elution with petroleum ether/ acetone (4/1, v/v) or crystallization in ethyl ether gave the corresponding pure 1 -hydroxyalkylphosphonate. 

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