Trichloro toluene

It may be synthesised by several methods. The industrial synthesis starts with 2-chlorotoluene, which is chlorinated to a mixture of 2,3,6- and 2,4,6-trichloro-toluenes. The resulting intermediate is then oxidised to the corresponding trichlorobenzoic acids, containing about 60% TBA and 40% 2,4,5-trichloroben-zoic acid. 

Beilstein Handbook Reference) AI3-02583 Benzene, trichloromethyl)- Benzenyl trichloride Benzoic trichloride Benzotrichloride Benzolrlcloruro Benzyl trichloride Benzylidyne chloride BRN 0508152 CCRIS 1292 Chloruie de benzenyle Chlorure de benzylidyne EINECS 202-634-5 HSDB 2076 NSC 14663 Phenyl chloroform Phenyltrichloromethane RCRA waste a,a,a,-trichloro- Toluene trichloride ... 

Dechlorothiolation. Activated trichloromethyl groups (e.g., in RCOCCI3) are converted to the benzenethiomethyl residues using PhSH-PhSNa. Both substitution and hydrodechlorination occur on such treatment. However, chloroform and a,a,ct-trichloro-toluene do not react in the same manner. 

Toluene-2,5-diamine 6980 2,4,5-Trichloro toluene 10252 Trimethylene sulfide 10038... 

Cm.OROCARBONSANDCm.OROHYDROCARBONS - RDIG-Cm.ORINATED TOLUENES] (Vol 6) N2,N4,N6-Trichloro-2,4,6 triamino-l,3,5-tria2ine [12379-38-3]... 

Trichloro- and dichloromethane, ether, dioxane, benzene, toluene, chlorobenzene, acetonitrile, or even pyridine itself has been employed to carry out the one-pot syntheses. Tliese solvents allow straightforward preparation of the salts. The temperature range between 0° and 20°C is usually employed and the salts formed are sufficiently soluble. In the case of slow reactions, selection of a solvent with a higher boiling point is prohtable since thermal instability of the A -(l-haloalkyl)heteroarylium halides has not been reported. Addition of water or an aqueous solution of sodium acetate does not cause a rapid decomposition of the salts so that this constitutes a useful step in the optimization of some procedures. 

A. Toluene diisocyates (TDI), xylene isocyanates, chloro-TDI, bromo-TDI, dichloro-TDI, and trichloro-TDI... 

All reported syntheses of TATB to date involve the nitration of substrates containing leaving groups which are subsequently replaced by amino groups. The current industrial synthesis of TATB (14) involves the nitration of 1,3,5-trichlorobenzene (33) to 1,3,5-trichloro-2,4,6-trinitrobenzene (34) followed by reaction with ammonia in toluene under pressure. Both nitration and amination steps require forced conditions with elevated temperatures. 

The nitration of l,3,5-trichloro-2-nitrobenzene (8) to l,3,5-trichloro-2,4-dinitrobenzene (9) with dinitrogen pentoxide in absolute nitric acid goes to completion in only 2-4 minutes at 32-35 °C. Further nitration of (9) would yield l,3,5-trichloro-2,4,6-trinitrobenzene (10) which undergoes ammonolysis on treatment with ammonia in toluene to give the thermally stable explosive 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) (11). The same sequence of reactions with l,3-dichloro-2-nitrobenzene provides a route to l,3-diamino-2,4,6-trinitrobenzene (DATE). Such reactions are clean and occur in essentially quantitative yield. 

Manufacturing processes in which organic products are made are of special interest to green chemists for a variety of reasons, largely because so many of the raw materials used to make such products, the by-products formed in the reactions, and the final products themselves are likely to he toxic or hazardous in other ways. Historically, the problem with such manufacturing processes is that they have required the use of organic solvents, such as carbon tetrachloride, chloroform, tetrachloroethylene, trichloroethylene, 1,1,1-trichloro-ethane, benzene, toluene, and xylene. A major thrust, then, has been to find satisfactory substitutes for these organic solvents. 

Recently, experimental data of S for various liquid-crystalline polymer solutions have become available. Figure 12 illustrates the concentration dependence of S for three polymer liquid crystal systems (a) PBLG-DMF [92,93], (b) PHIC-toluene [94], and (c) poly(yne)-platinum polymer (PYPt)-trichloro-ethane (TCE) [33]. For systems (a) and (c), with the alignment made by... 

Synonyms. Benzenyl chloride benzenyl trichloride benzylidyne chloride benzyl trichloride phenyl chloroform phenyltrichloromethane toluene trichloride trichloro-methylbenzene... 

Of numerous chloral condensations with aromatic hydrocarbons the most interesting for the synthesis of condensation monomers are the reactions with benzene [3], toluene [4], acenaphthene [5], phenol [6], anisol [7], acetanilide [8] and halobenzenes like chlorobenzene [9] and fluorobenzene [10]. In general terms, these reactions proceed according to Scheme 2.2 and give the desired 1,1,1-trichloro-... 

Reactions using catecholborane proceed smoothly in toluene (Scheme 16) (40). The utility of catalytic hydroboration of ketones has been demonstrated by the efficient enantioselective synthesis of a series of biologically active compounds (41). Scheme 17 shows some compounds prepared by using this method. Enantioselective reduction of trichloro-methyl ketones is a general route to a-amino acids and a-hydroxy esters it also allows ready synthesis of a precursor to the carbonic anhy-drase inhibitor MK-0417 (42). 

The reactions of tris(2-hydroxyphenyl)amine with trichloro-, trimethoxy- or triace-toxysilanes in boiling toluene afford the corresponding Si-substituted derivatives instead... 

Allcock and coworkers reported that trichloro(trimethylsilyl)phosphor-animine 19b polymerized with PCI5 at ambient temperature with elimination of trimethylsilyl chloride. The resultant poly(dichlorophosphazene) was treated with an excess of NaOCH2CF3 to give polymer 20. When the polymerization was carried out in dichloromethane, the molecular weight increased with increase in the ratio of 19b to PCI5 (Mw = 7000-14 000), and the molecular weight distribution was kept narrow (Mw/Mn = 1.04-1.20) [274]. The polymerization in toluene proceeded faster than in dichloromethane to give... 

The use of extracellular lipases of microbial origin to catalyze the stereoselective hydrolysis of esters of 3-acylthio-2-methylpropionic acid in an aqueous system has been demonstrated to produce optically active 3-acylthio-2-methyl-propionic acid [41-43], The synthesis of the chiral side chain of captopril by the lipase-catalyzed enantioselective hydrolysis of the thioester bond of racemic 3-acetylthio-2-methylpropionic acid (15) to yield 5 -(-)-(15) has been demonstrated [44], Among various lipases evaluated, lipase from Rhizopus oryzae ATCC 24563 (heat-dried cells), BMS lipase (extracellular lipase derived from the fermentation of Pseudomonas sp. SC 13856), and lipase PS-30 from Pseudomonas cepacia in an organic solvent system (l,l,2-trichloro-l,2,2-tri-fluoroethane or toluene) catalyzed the hydrolysis of thioester bond of undesired enantiomer of racemic (15) to yield desired S-(-) (15), R-(+)-3-mercapto-2-methylpropionic acid (16) and acetic acid (17) (Fig. 8A). The reaction yield of... 

---