Triazine metabolites

Mills and Thurman [105] studied the mixed mode isolation of Triazine metabolites from soils using automated solid phase extraction with methanohwater (4 lu/u) extracts of the sample. Methanol is evaporated from the extract and the metabolites are collected on an octadecyl resin (Cl8) column. The analytes are eluted with ethyl acetate leaving the impurities on the C18 resin column. The detection limit of this method is 0-lgg kg 1-... 

Chloroguanide hydrochloride (Paludrine) is activated to a triazine metabolite, cycloguanil, which also interferes with parasite folic acid synthesis. It is a dihydrofolate reductase inhibitor that is used for the prophylaxis of malaria caused by all susceptible strains of plasmodia. Chloroguanide is rapidly absorbed from the gas-... 

The active triazine metabolite, inhibits plasmodial dihydrofolate reductase and thus disrupts the synthesis of nucleic acids in the parasite. 

Mills et al. [367] have described a method for the isolation of triazine metabolites from soil using automated solid-phase extraction with methanol water... 

One extraction phase developed for triazines is graphitized carbon black, which has been shown to be versatile for a wide range of pesticides (Di Corcia et al, 1987 Di Corcia and Marchetti, 1992 Di Corcia et al., 1993 Bucheli et al, 1997 Crescenzi et al, 1997). It has also been shown to be very effective for retaining the more polar metabolites (e.g., deisopropylatrazine (DIA), deethylatrazine (DEA), and hydroxyatrazine (ATOH) see Table 20.1, also Appendix, Table A3) (Berg et al, 1995 Di Corcia et al, 1997 Pichon et al, 1995 Schulein et al., 1995). The methods published require considerably more column preparation and elution steps than traditional Cl8 methods. Pichon et al. (1995) also included the polar triazine metabolites ammeline, ammelide, and cyanuric acid, with good recoveries using a graphitic carbon sorbent. 

Mills, M.S. and E.M. Thurman (1992). Mixed-mode isolation of triazine metabolites from soil and aquifer sediments using automated solid-phase extraction. Anal. Chem., 64(17) 1985-1990. 

Bottoni, P., J. Keizer, and E. Funari (1996). Leaching indices of some major triazine metabolites. Chemosphere, 32 1401-1411. 

Scribner, E.A., D.A. Goolsby, E.M. Thurman, M.T. Meyer, and M.L. Pomes (1994). Concentrations of selected herbicides, two triazine metabolites, and nutrients in storm runoff from nine stream basins in the midwestem US, 1990-1992. USGS Open-File Report 94-396. 

The Hill reaction inhibiting effect of triazine herbicides has been investigated by Exer (1958), while Gysin and Kniisli (1960) investigated this effect for a few triazine metabolites (Tables 13 and 14). The Hill reaction inhibiting values of several important triazines have been summarised by Moreland (1969) and Gabbot (1969). 

Proguanil and its triazine metabolite cycloguanil have the following structures ... 

---