Tremors dysfunction

SSRIs are well tolerated. Adverse effects for compounds in this class include nervousness, tremor, dizziness, headache, insomnia, sexual dysfunction, nausea, and diarrhea. In addition, the tricycHc antidepressant clomipramine (33), which is a potent nonselective serotonin reuptake inhibitor, is approved for treatment of obsessive—compulsive disorder. 

SSRIs are widely used for treatment of depression, as well as, for example, panic disorders and obsessive—compulsive disorder. These dmgs are well recognized as clinically effective antidepressants having an improved side-effect profile as compared to the TCAs and irreversible MAO inhibitors. Indeed, these dmgs lack the anticholinergic, cardiovascular, and sedative effects characteristic of TCAs. Their main adverse effects include nervousness /anxiety, nausea, diarrhea or constipation, insomnia, tremor, dizziness, headache, and sexual dysfunction. The most commonly prescribed SSRIs for depression are fluoxetine (31), fluvoxamine (32), sertraline (52), citalopram (53), and paroxetine (54). SSRIs together represent about one-fifth of total worldwide antidepressant unit sales. 

SSRIs are the drugs of choice for PD. All SSRIs have demonstrated effectiveness in controlled trials, with 60% to 80% of patients achieving a panic-free state.28,48,49 With similar efficacy reported and no trials comparing SSRIs with other SSRIs, selection generally is based on pharmacokinetics, drug interactions, side effects, and cost differences (see Chap. 35 for more discussion). The most common side effects of SSRIs include headaches, irritability, nausea and other gastrointestinal complaints, insomnia, sexual dysfunction, increased anxiety, drowsiness, and tremor.49 SSRIs should not be discontinued abruptly to avoid a withdrawal syndrome characterized by dysphoric mood, irritability, and agitation. 

Cyclosporine reduces production of cytokines involved in T-cell activation and has direct effects on B cells, macrophages, bone, and cartilage cells. Its onset appears to be 1 to 3 months. Important toxicities at doses of 1 to 10 mg/kg/day include hypertension, hyperglycemia, nephrotoxicity, tremor, GI intolerance, hirsutism, and gingival hyperplasia. Cyclosporine should be reserved for patients refractory to or intolerant of other DMARDs. It should be avoided in patients with current or past malignancy, uncontrolled hypertension, renal dysfunction, immunodeficiency, low white blood cell or platelet counts, or elevated Ever function tests. 

Significant adverse reactions include edema vaginitis nervousness emotional lability hepatic dysfunction elevated blood pressure pelvic pain carpal tunnel syndrome sleep disorders fatigue tremor visual disturbances anxiety depression gastroenteritis. 

Hepatic function impairment In patients with preexisting severe liver disease, hepatic encephalopathy (manifested by tremors, confusion, and coma, and increased jaundice) may occur. Because amiloride is not metabolized by the liver, drug accumulation is not anticipated in patients with hepatic dysfunction, but accumulation can occur if hepatorenal syndrome develops. 

MDD. Adverse reactions occurring in at least 3% of patients include the following abnormal orgasm, anxiety, blurred vision, constipation, decreased appetite/anorexia, decreased libido, delayed ejaculation, diarrhea, dizziness, dry mouth, ejaculatory dysfunction, erectile dysfunction, fatigue, increased sweating, insomnia, nausea, somnolence, tremor, vomiting. 

The principal adverse reactions of tacrolimus are tremor, headache, diarrhea, hypertension, nausea, and renal dysfunction. Other reactions may include insomnia, paresthesia, constipation, anorexia, vomiting, anemia, leukocytosis, thrombocytopenia, hyperglycemia, dyspnea, pruritus, rash, abdominal pain, fever, asthenia, back pain,... 

Adverse reactions may include renal dysfunction tremor infectious complications hirsutism hypertension gum hyperplasia cramps acne convulsions paresthesia. Methotrexate... 

Elemental citability, emotional instability, depression, insomnia), motor dysfunction (tremors)... 

The adverse effects of valacyclovir and acyclovir are similar. Toxicity is generally minimal, consisting largely of headache, nausea, and diarrhea. Less frequently observed are skin rash, fatigue, fever, hair loss, and depression. Reversible renal dysfunction (azotemia) and neurotoxicity (tremor, seizure, delirium) are dose-Umiting toxicides of intravenous acyclovir. Adequate hydration and slow drug infusion can minimize the risk of renal toxicity. 

CNS Bowel Dysfunction Bladder Dysfunction Falls Other Tachycardia, Psychosis, Tremor... 

Anorexia, anxiety, tremor, vomiting, flatulence, urinaryfrequency, sexual dysfunction, altered taste... 

Of particular importance in the geriatric patient Case reports of organic brain syndrome, cognitive impairment, ataxia, cerebellar dysfunction, AV block, edema, tremor, renal impairment, nephrogenic diabetes insipidus, urinary frequency, hypothyroidism, leukocytosis, weight gain... 

Sedation, tremor, dry mouth, insomnia, agitation, hyperactivity, erectile dysfunction AE s mostly transient Insomnia, nausea, agitation and tremor... 

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