Trapped ion mobility spectrometry

Infrared spectroscopy Ion trap ion mobility spectrometry Littoral combat ship Light-emitting diode... 

L., Cherbas, P., Kaufinann, T. C., Miller, D. F., Mechref, Y., Novotny, M. V, Ewing, M. A., Sporleder C. R., Clemmer, D. E. (2003) Development of high-sensitivity ion trap ion mobility spectrometry time-of-flight techniques a high-throughput nano-LC-IMS-TOF separation of peptides arising from a Drosophila protein extract. Anal Chem, 75, 5137-5145. 

Creaser, C. S. Griffiths, J. R. Stockton, B. M., Gas-phase ion mobility studies of amines and polyether/amine complexes using tandem quadrupole ion trap/ion mobility spectrometry , European Journal of Mass Spectrometry 2000, 6, 213-218. 

The trace detection portal manufactured and marketed by General Electric (GE) Security is called the EntryScan3 [34], shown in Fig. 4. This portal was the result of a collaborative development effort between Ion Track Instruments (ITI), which was later acquired by GE, and Pennsylvania State University (Penn State), funded by the TSL [4,5,23,32], The detection method used in this portal is ion mobility spectrometry (IMS) [35], GE utilizes their patented Ion Trap Mobility Spectrometer (ITMS) for detection [36],... 

SC Flenderson, SJ Valentine, AE Counterman, DE Clemmer. ESI/ion trap/ion mobility/time-of-flight mass spectrometry for rapid and sensitive analysis of biomolecular mixtures. Anal Chem 71 291—301, 1999. 

Cui, M. Ding, L. Mester, Z. Separation of Cisplatin and Its Hydrolysis Products Using Electrospray Ionization High-Field Asymmetric Waveform Ion Mobility Spectrometry Coupled with Ion Trap Mass Spectrometry, Anal. Chem. 75, 5847-5853 (2003). 

One more feature is its potential for measuring stereo-, positional and conformational isomers as well as isotopomers in gas-phase species, as was illustrated in Chapter 6. The combination of ion-trap mass spectrometry and ion mobility spectrometry with MMW spectrometry to quantify isomer ratios is surely a proposition worth investigation. The vacuum system in the mass spectrometer is already in place and the ions can be held in position for an extended period in ion traps. There may be time enough to make multiple scans and obtain the spectra of the different isomeric forms or their fragments even at the low abundance characteristic of mass spectrometry systems. 

Colgrave, M., Nanoelectrospray ion mobility spectrometry and ion trap mass spectrometry studies of the non-covalent complexes of amino acids and peptides with polyethers, Int. J. Mass Spectrom. 2003, 229, 209—216. 

Hoaglund-Hyzer, C.S. Clemmer, D.E., Ion trap/ion mobility/quadrupole/time-of-flight mass spectrometry for peptide mixture analysis. Anal. Chem. 2001, 73, 177-184. 

FIGURE 9.3 Contourplots of nested drift time (bottom) and flight time (left) data for amix-ture of peptide ions that were formed by direct electrospray of a tryptic digest of cytochrome c. Projection of the data along the bottom and left axes shows ion mobility and time-of-flight dis-tribntions, respectively. (Taken from Henderson et al., ESI/ion trap/ion mobility/time-of-flight mass spectrometry for rapid and sensitive analysis of biomolecnlar mixtures, Anal. Chem. 1999, 71, 291. With permission.)... 

Cui, M., Ding, L., Mester, Z., Separation of cisplatin and its hydrolysis products using electrospray ionization high-held asymmetric wayeform ion mobility spectrometry coupled with ion trap mass spectrometry. Anal. Chem. 2003, 75, 5847. 

In the Prefaces to Volumes 4 and 5 of Practical Aspects of Trapped Ion Mass Spectrometry the Editors have explained that, in defining the scope of these publications, it is considered that an ion is trapped when its residence time within a defined spatial region exceeds that had the motion of the ion not been impeded in some way. Ion mobility spectrometry ( IMS ) operated at atmospheric pressure, which falls clearly within this definition, involves the determination of the time taken for the components of a packet of ions to move through a defined distance under the influence of a specified electric field gradient and against the connter current flow of a drift gas at ambient pressure. 

We describe here the important role that quadrupole ion traps (both the classic 3D ion trap and the linear ion trap) have played, and will continue to play, in imaging mass spectrometry (IMS) (which is not to be confused with Ion Mobility Spectrometry (IMS)). The pulsed mode of operation of an ion trap is an ideal match to a pulsed laser desorption event. Even more important, quadrupole ion traps provide Mass spectrometry/Mass spectrometry MS/MS (and MS"), which is critical for the mapping of individnal compounds in complex samples such as tissue, and for... 

During the last few decades, an increasing number of different breath analysis techniques have been developed for the analysis of VOCs. These techniques include gas chromatography/flame ionization detection (GC/ FID), gas chromatography-mass spectrometry (GC-MS) (with quadrupole mass spectrometry, ion trap mass spectrometry, time-of-flight (TOF) tube mass spectrometry, and ion mobility spectrometry), soft ionization flow tube mass spectrometry (SIFT-MS), chemiluminescence, electronic nose, and a large variety of optical absorption detection techniques. The multitude of methods and techniques used in breath analysis reflects not only its strength, but also its weakness. On one hand, there is a choice of sensitive techniques suitable to measure almost any compound on the other hand, it makes it very hard to compare all the various results. 

The use of theoretical and computational methods in 2011 has continued to rise phenomenally in accordance with Moore s law. These methods are covered comprehensively in the second section of the Physical Methods chapter. This year s highlights include confirmation of the four conformations of trimethylphosphite by matrix isolation infrared spectroscopy supported by ab initio calculations. The trimethylphosphite was trapped in a N2/Ar matrix and deposited onto a cold KBr substrate at 12 K for analysis. For the first-time a complete and accurate vibrational frequency assignment was performed on Dimethoate from vibrational spectroscopy and theoretical calculations. Ion Mobility Spectrometry, as a stand-alone technique from Mass Spectrometry, was used in the detection of chemical nerve agents, which also have attracted an increasing use of rapid electrochemical sensors. 

MALDI-Fourier transform ion cyclotron resonance mass spectrometry MALDI-Q-ion mobility-TOFMS MALDI-Quadrupole-ion-trap-TOF mass spectrometry MALDI-TOF-imaging mass spectrometry MALDI Time-of-flight mass spectrometry Magnetic resonance imaging Matrix solution fixation Moxifloxacin... 

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