Inhibition of glycoprotein

Humans and animals are affected by genetic diseases that occur as a result of inhibition of glycoprotein-processing enzymes (reviewed by James et al., 2004). These diseases are collectively known as lysosomal storage diseases. The animal diseases, genetic or induced, have counterparts in humans. For example ... 

In contrast to the inactive parent compound 2, inhibition of glycoprotein-processing oc-glucosidases was also found by Butters and coworkers for 1-deoxynojirimycin derivatives having phenylalkyl substituents of medium chain lengths (C4—C6) at the ring nitrogen atom.359... 

Thioguanine (6-TG) also inhibits several enzymes in the de novo purine nucleotide biosynthetic pathway. Various metabolic lesions result, including inhibition of purine nucleotide interconversion decrease in intracellular levels of guanine nucleotides, which leads to inhibition of glycoprotein synthesis interference with the formation of DNA and RNA and incorporation of thiopurine nucleotides into both DNA and RNA. 6-TG has a synergistic action when used together with cytarabine in the treatment of adult acute leukemia. 

N-nonyl deoxynoj irimy cin Anti-viral Inhibition of glycoprotein folding IgX Oxford Hepatitis... 

Rosenwald AG, Pagano RE. Inhibition of glycoprotein traffic through the secretory pathway by ceramide. J Biol Chem 268(1993) 4577-4579. 

The metabolism of deoxyfluoro sugars has been studied in relation to the inhibition of glycoprotein biosynthesis. Thus, 2-deoxy-2-fluoro-D-glucose (2FG) and... 

Puromycin. Puromycin (19), elaborated by S. alboniger (1—4), inhibits protein synthesis by replacing aminoacyl-tRNA at the A-site of peptidyltransferase (48,49). Photosensitive analogues of (19) have been used to label the A-site proteins of peptidyltransferase and tRNA (30). Compound (19), and its carbocycHc analogue have been used to study the accumulation of glycoprotein-derived free sialooligosaccharides, accumulation of mRNA, methylase activity, enzyme transport, rat embryo development, the acceptor site of human placental 80S ribosomes, and gene expression in mammalian cells (51—60). 

BVdU is incorporated into DNA, but since it is phosphorylated specifically in the viraHy infected cell, incorporation is mainly confined to such cells. Evidence suggests that BVdU also inhibits the biosynthesis of HSV-1 glycoproteins, which may contribute to the inhibition of the HSV-1 vims (32). 

Inhibition of human multidrug resistance P-glycoprotein 1 was investigated by analogs of a potent. 5-opioid antagonist, including (35, 1 lu5)-3-[(4-hydroxy-2,6-dimethylphenyl)methyl]-11,11 u-dihydro-2//-pyrazino[l, 1-b] isoquinoline-l,4(3//,6//)-dione (OIMIIO). Opioid antagonist activity of... 

An overview of the role of the virus-associated glycoprotein sialidase (neuraminidase) and some of the most recent developments towards the discovery of anti-influenza drugs based on the inhibition of influenza virus sialidase is provided in this chapter. 

Jiang S, Lin K, Strick N, Neurath AR (1993) Inhibition of HIV-1 infection by a fusion domain binding peptide from the HIV-1 envelope glycoprotein GP41. Biochem Biophys Res Commun 195 533-538... 

Not all transporters, however, show the same preferential directions. Lee and coworkers also have discovered a pump glycoprotein in the conjunctiva with preferential flux directed toward the mucosal side of the tissue. This transporter has been shown to restrict conjunctival absorption of therapeutic agents such as cyclosporin A, verapamil, and dexamethasone. In some circumstances, transient inhibition of such xe-nobiotic transporters might be an effective means of increasing the efficacy of particular classes of therapeutic agents. 

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