Transport interstitial

In the third part of this article (Section IV), various physiological and transport parameters relevant to heat and mass transfer are compiled. These parameters include vascular morphology, blood flow, transvascular transport, interstitial transport, and thermal and metabolic properties. It... 

Increased interstitial fluid pressure (IFP) within solid tumors decreases extravasation and inhibits the extravascular transport of larger molecules (e.g., monoclonal antibodies, cytokines) by convection (see Table 15.2). Macromolecules rely more heavily on convection as opposed to simple diffusional transport. Interstitial transport of macromolecules is further impaired by a much denser network of collagen fibers in the extracellular matrix of tumors as compared to normal tissues. CoUagen content in tumors is much higher and collagen fibers are much thicker than in normal tissues, leading to an increased mechanical stiffness of the tissue (Netti et al. 2000 Heldin et al. 2004). 

Transport in the blood is no longer a requisite for a hormonal response. Responses can occur after release of hormones into the interstitial fluid with binding to receptors in nearby ceUs, called paracrine control, or binding to receptors on the ceU that released the hormone, called autocrine control. A class of hormones shown to be synthesized by the tissue in which they act or to act in the local ceUular environment are the prostaglandins (qv). These ubiquitous compounds are derived from arachidonic acid [506-32-1] which is stored in the ceU membranes as part of phosphoHpids. Prostaglandins bind to specific ceUular receptors and act as important modulators of ceU activity in many tissues. 

A fundamental difference exists between the assumptions of the homogeneous and porous membrane models. For the homogeneous models, it is assumed that the membrane is nonporous, that is, transport takes place between the interstitial spaces of the polymer chains or polymer nodules, usually by diffusion. For the porous models, it is assumed that transport takes place through pores that mn the length of the membrane barrier layer. As a result, transport can occur by both diffusion and convection through the pores. Whereas both conceptual models have had some success in predicting RO separations, the question of whether an RO membrane is truly homogeneous, ie, has no pores, or is porous, is still a point of debate. No available technique can definitively answer this question. Two models, one nonporous and diffusion-based, the other pore-based, are discussed herein. 

For an ion to move through the lattice, there must be an empty equivalent vacancy or interstitial site available, and it must possess sufficient energy to overcome the potential barrier between the two sites. Ionic conductivity, or the transport of charge by mobile ions, is a diffusion and activated process. From Fick s Law, J = —D dn/dx), for diffusion of a species in a concentration gradient, the diffusion coefficient D is given by... 

Finally we notice that in the p-type oxides CU2O and NiO, the presence of excess oxygen actually provides, through the formation of cation vacancies, a transport mechanism for the metal, while in an /i-type oxide like TiOi, the excess metal, by forming anion vacancies, provides a transport mechanism for oxygen. With /i-type oxides like ZnO and AljO, where the excess metal is accommodated interstitially, a transport mechanism is, of course, provided for the excess component itself. 

Lipoprotein metabolism is the process by which hydrophobic lipids, namely triglycerides and cholesterol, are transported within the interstitial fluid and plasma. It includes the transport of energy in the form of triglycerides from intestine and liver to muscles and adipose, as well as the transport of cholesterol both from intestine and liver to peripheral tissues, as well as from peripheral tissues back to the liver. 

Substrate specificity is determined by high affinity for the cognate neurotransmitter substrate. However, low affinity uptake does also have a part in the clearance of transmitters from the interstitial space (e.g., in uptake mediated by the extraneuronal monoamine transporter, EMT) and in the intestinal absoiption of glycine and glutamate. It is obvious that there is an evolutionary relation of neurotransmitter transporters and amino acid and cation transporters in epithelia. 

GABA transporter GAT1 (SLC6A1) GABAergic neurons in CNS <10 Clearance of interstitial neurotransmitter, reuptake into neurons Tiagabine, an antiepileptic drug... 

Glycine transporter GlyTl (SLC6A9) CNS-glia -20 Clearance of interstitial neurotransmitter Sarcosine... 

Oedema refers to an accumulation of interstitial fluid to a point where it is palpable or visible. In general this point is reached with a fluid volume of 2-3 liters. Oedema formation is the result of a shift of fluid into the interstitial space due to primary disturbances in the hydraulic forces governing transcapillary fluid transport and of subsequent excessive fluid reabsorption by the kidneys. Deranged capillary hydraulic pressures initiate oedema formation in congestive heart failure, and liver cirrhosis whereas a deranged plasma oncotic pressure... 

Characteristically, the mechanisms formulated for azide decompositions involve [693,717] exciton formation and/or the participation of mobile electrons, positive holes and interstitial ions. Information concerning the energy requirements for the production, mobility and other relevant properties of these lattice imperfections can often be obtained from spectral data and electrical measurements. The interpretation of decomposition kinetics has often been profitably considered with reference to rates of photolysis. Accordingly, proposed reaction mechanisms have included consideration of trapping, transportation and interactions between possible energetic participants, and the steps involved can be characterized in greater detail than has been found possible in the decompositions of most other types of solids. 

The sediment surface separates a mixture of solid sediment and interstitial water from the overlying water. Growth of the sediment results from accumulation of solid particles and inclusion of water in the pore space between the particles. The rates of sediment deposition vary from a few millimeters per 1000 years in the pelagic ocean up to centimeters per year in lakes and coastal areas. The resulting flux density of solid particles to the sediment surface is normally in the range 0.006 to 6 kg/m per year (Lerman, 1979). The corresponding flux density of materials dissolved in the trapped water is 10 to 10 kg/m per year. Chemical species may also be transported across the sediment surface by other transport processes. The main processes are (Lerman, 1979) ... 

Diffusion as referred to here is molecular diffusion in interstitial water. During early diagenesis the chemical transformation in a sediment depends on the reactivity and concentration of the components taking part in the reaction. Chemical transformations deplete the original concentration of these compounds, thereby setting up a gradient in the interstitial water. This gradient drives molecular diffusion. Diffusional transport and the kinetics of the transformation reactions determine the net effectiveness of the chemical reaction. 

Fig. 14-4 Schematic representation of the transport of P through the terrestrial system. The dominant processes indicated are (1) mechanical and chemical weathering of rocks, (2) incorporation of P into terrestrial biomass and its return to the soil system through decomposition, (3) exchange reactions between soil interstitial waters and soil particles, (4) cycling in freshwater lakes, and (5) transport through the estuaries to the oceans of both particulate and dissolved P.

Testiculat androgens are synthesized in the interstitial tissue by the Leydig cells. The immediate precursor of the gonadal steroids, as for the adrenal steroids, is cholesterol. The rate-limiting step, as in the adrenal, is delivery of cholesterol to the inner membrane of the mitochondria by the transport protein StAR. Once in the proper location, cholesterol is acted upon by the side chain cleavage enzyme P450scc. The conversion of cholesterol to pregnenolone is identical in adrenal, ovary, and testis. In the latter two tissues, however, the reaction is promoted by LH rather than ACTH. 

Point defects in solids make it possible for ions to move through the structure. Ionic conductivity represents ion transport under the influence of an external electric field. The movement of ions through a lattice can be explained by two possible mechanisms. Figure 25.3 shows their schematic representation. The first, called the vacancy mechanism, represents an ion that hops or jumps from its normal position on the lattice to a neighboring equivalent but vacant site or the movement of a vacancy in the opposite direction. The second one is an interstitial mechanism where an interstitial ion jumps or hops to an adjacent equivalent site. These simple pictures of movement in an ionic lattice, known as the hopping model, ignore more complicated cooperative motions. 

Solid mixed ionic-electronic conductors (MIECs) exhibit both ionic and electronic (electron-hole) conductivity. Naturally, in any material there are in principle nonzero electronic and ionic conductivities (a i, a,). It is customary to limit the use of the term MIEC to those materials in which a, and 0, 1 do not differ by more than two orders of magnitude. It is also customary to use the term MIEC if a, and Ogi are not too low (o, a i 10 S/cm). Obviously, there are no strict rules. There are processes where the minority carriers play an important role despite the fact that 0,70 1 exceeds those limits and a, aj,i< 10 S/cm. In MIECs, ion transport normally occurs via interstitial sites or by hopping into a vacant site or a more complex combination based on interstitial and vacant sites, and electronic (electron/hole) conductivity occurs via delocalized states in the conduction/valence band or via localized states by a thermally assisted hopping mechanism. With respect to their properties, MIECs have found wide applications in solid oxide fuel cells, batteries, smart windows, selective membranes, sensors, catalysis, and so on. 

In the alveolar-interstitial region, human lung clearance has been measured. The ICRP model uses two half-times to represent clearance about 30% of the particles have a 30-day half-time, and the remaining 70% are assigned a half-time of several hundred days. Over time, AI particle transport falls, and some compounds have been found in lungs 10-50 years after exposure. 

LT Baxter, RK Jain. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc Res 37 77-104, 1989. 

Compartment 1 represents the vascular space of the tissue and can be identified as either a blood, plasma, or serum space. Compartment 2 is the interstitial space, and compartment 3 the intracellular tissue volume. Assuming first-order or linear membrane transport for the drug, the flux terms can be expanded as... 

---