Transport Classification Database

Membrane Transport Classification Databases. Available on line at http //tcdb.ucsd.edu/tcdb http //www.gene.ucl. ac.uk/nomenclature/genefamily.shtml. 

Receptors of this type are activated by an ionic flux that modulates the opening of a channel and selectively regulates the entry of ions into the cell. At least two classification schemes for ion channels coexist today, viz., the one established by the NC-IUPHAR and the alternative scheme approved by the NC-IUBMB based on the Transport Classification Database. ... 

Saier, M. H., Jr., Tran, C. V., et al. (2006). TCDB The Transporter Classification Database for membrane transport protein analyses and information. Nucleic Acids Research, 34(Database issue), D181-D186. 

The other class of nudeoside transporter expressed in spedalized mammalian cells, designated Concentrarive Nucleoside Transporter (CNT) because nudeoside uptake is coupled with the cell s dectrochemical gradient (Family 2A.41 in the Transporter Classification Database, http //www.tcdb.org), appears to be absent in Leishmania parasites based upon bioinformaric analyses of the available genome databases. 

ABC transporters (Transporter classification [TC] number 3.A.1 according to the Transport Classification Database [www.tcdb.org] and TransportDB [www.membranetransport.org]), or ff-dependent (Fig. 1). Up to now, no A P-dependent transport process has been described. 

A comprehensive list of all annotated transport proteins is freely available online on the TCDB website (http //www.tcdb.org). This Transporter Classification Database uses an International Union of Biochemistry and Molecular Biology (lUBMB) approved system of nomenclature for transport protein classification. The TC system is analogous to the Enzyme Commission (EC) system for classification of enzymes, except that it incorporates both functional and phylogenetic information (Saier et al., 2006 Saier et al., 2009). 

Saier, M.H., Yen, M.R., Noto, K, Tamang, D.G. Elkan, C. (2009). The Transporter Classification Database recent advances. Nucleic Acids Res, Vol.37, No.suppl 1, pp. D274-D278... 

The MIP (major intrinsic protein TC 1.A.8 in the Transporter Classification Database (TCDB www.tcdb.org)) family of aquaporins and glycerol facilitators were found in the 11 bacteria originally studied. Proteins in this family facilitate the passage of several neutral molecules such as water, glycerol, dihydroxyacetone, CO, urea, and ammonia (Jensen et al. 2002 Carbrey et al. 2003 Uehlein et al. 2003). All the microorganisms analyzed have at least one member of this family while some have up to five members (Table 4.1). 

Material safety data sheets should list information which permits proper classification of material. A broad range of transportation data for specific materials is included in the Database of Antiblocking, Release, and Slip Agents. Transportation information in the database includes UN Risk Phrases, UN Safety Phrases, DOT Hazard Class, UN/NA, ADR/RID Class, ICAO/IATA Class, and IMDG Class which are required for transportation by air, water and land. 

Databases are a convenient and easy way to access chemical safety information. Many databases that include topics of chemical safety are available worldwide. The databases may contain literature references to general information on chemical safety, numerical values for safety characteristics, toxicological data, and/or regulations for transport and classifications of dangerous goods. 

Table 1 lists the most important databases including information on chemical safety. The Contents column classifies the main contents of the database GEN = general information on chemical safety, NUM = numerical data for safety characteristics (for example flash points, explosion limits), TOX = toxicological data, CLA = classifications for transportation, handling and storage. If the term is shown in brackets, for example (NUM), the database has its main focus on a different topic, but data according to the term in brackets may be found there also. 

Databases like CHEMLIST, TRANSPORT, or the EINECS plus CD-ROM can be recommended, if classification for transportation and storage of chemical substances is needed. 

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