Transgenerational

A two-generational study in pregnant rats exposed to 538 ppm 1,4-dichlorobenzene via inhalation produced decreased survival and decreased body weights in Fj pups (Tyl and Neeper-Bradley 1989). Murthy et al. (1987) reported morphologically abnormal sperm in rats exposed to 800 mg/kg/day by intraperitoneal injection. There are no studies that report transgenerational effects of exposure to... 

Nice H.E., D. Morritt, M. Crane, and M. Thomdyke (2003). Long-term and transgenerational effects of nonylphenol exposure at a key stage in the development of Crassostrea gigas. Possible endocrine disruption Marine Ecology Progress Series 256 293-300. 

Blatt J, Van Le L, Weiner T, Sailer S. Ovarian carcinoma in an adolescent with transgenerational exposure to diethylstilbestrol. J Pediatr Hematol/Oncol 2003 25 635-6. 

There is no information regarding possible transgenerational effects of DEHP in humans. A dominant lethal test in mice reported no significant effects (pregnancy rate, live fetuses, early and late fetal deaths) after treating male mice with DEHP (up to 9,860 mg/kg/day), MEHP (up to 200 mg/kg/day), or 2-ethylhexanol (up to 1,000 mg/kg/day) and then mating them with virgin females (Rushbrook et al. 1982). 

Atienzar FA, Jha AN. 2004, The random amplified polymorphic DNA (R APD) assay to determine DNA alterations, repair and transgenerational effects in B(a)P exposed Daphnia magna. Mutat Res 552 125-140. 

M.D. Anway, A.S. Cupp, M. Uzumcu and M.K. Skinner, Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility, Science, 2005, 308, 1466. 

Anway, M.D., Skinner, M.K. (2006). Epigenetic transgenerational actions of endocrine disraptors. Endocrinology 147(6) (Suppl.) S43-9. 

Though EDCs can affect immunological responses, the most studied effects of EDCs are the reproductive and developmental ones. These, which include male and female reproductive disorders, transgenerational effects and developmental effects on the fetus in utero and the developing... 

The mechanisms for the effects of tobacco smoke on female fertility remain largely unknown. The transgenerational effect noted 11 js particularly without explanation. As noted previously, there are more than 4000... 

It has been recently established that paternal exposures to teratogenic effects can be transgenerationally transmitted. The following example illustrates this effect. 

Anway MD, Leathers C, Skinner MK. Endocrine disruptor vinclozolin induced epigenic transgenerational adult onset disease. Endocrinology2006 147(12) 5515 23. 

Anway MD, Leathers C, Uzumcu M, Skinner MK. Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis. J Androl 2006 27(6) 868 79. 

Skinner MK, Manikkam M, Guerrero-Bosagna C (2010) Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab 21(4) 214-222... 

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