Transgenerational Teratogenic Effects

It has been recently established that paternal exposures to teratogenic effects can be transgenerationally transmitted. The following example illustrates this effect. 

Embryonic exposure to vinclozolin, an antiandrogenic endocrine disruptor, has been shown to promote prostate disease, kidney disease, immune system abnormalities, testicular abnormalities, breast and other tumor development, and a number of blood abnormalities in the F1-F4 generations of laboratory animals. I8,91 The effects observed were noted in the adults of the four ensuing generations that followed the exposure. 

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