Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Topoisomerase inhibitors lung cancer

Topoisomerase inhibitor Lung, ovarian cancer OSI Pharm II... [Pg.484]

Lung Cancer Etoposide (VP-16) -plant alkaloid, topoisomerase II inhibitor -bone marrow suppression -nausea and vomiting -mucocutaneous effects (mucositis, stomatitis)—increased at higher doses -chemical phlebitis common -hypotension with rapid administration -hypersensitivity reactions -secondary leukemia... [Pg.172]

Patients with small cell lung cancer (the most aggressive type) show the best responses to platinum-based combination regimens, including cisplatin and etoposide or cisplatin and irinotecan. The topoisomerase I inhibitor topotecan is used as second-line monotherapy in patients who have failed a platinum-based regimen. [Pg.1320]

Covalently linked conjugates, (II), consisting of a topoisomerase I inhibitor such as a camptothecin group and a topoisomerase II inhibitor such as epipodophyllotoxin, were prepared by Lee (1) and used in treating small cell lung cancer. [Pg.600]

Topoisomerase II inhibitors consisting of phenylahistins, (V), and dehydropheny-lahistin derivatives, (VI), were prepared by Hayashi (4,5), respectively, and used in treating A-549 tumor cells derived from human lung cancer. [Pg.601]

Indications Acute lymphocytic leukemia, Non-Hodgkin s lymphoma, Small cell lung cancer Category Antineoplastic Topoisomerase 2 inhibitor Half-life 45 minutes... [Pg.555]

Topotecan hydrochloride is a DNA topoisomerase inhibitor. Topotecan hydrochloride is an antitumor drug with topoisomerase I-inhibitory activity. It is indicated in metastatic carcinoma of the ovary after failure of initial or subsequent chemotherapy small-cell-lung-cancer-sensitive disease after failure of first-line chemotherapy. [Pg.698]

Genistein, which is isolated from soy, inactivates Bcl-2 by phosphorylation, delays the G2/M phase of die cell cycle, and induces apoptosis of hiunan breast adenocarcinoma MCF-7 cells and it is also an inhibitor of protein tyrosine kinase and topoisomerase II (42). The natural estrogen metabolite 2-methoxyestradiol (2ME) is anti- angiogenic in vivo, can phosphorylate Bcl-2 and its mechanism of action is independent of die signaling enemies JNK/SAPK (41). The dolastatins are natural peptides, which inhibit microtubule assembly and induce apoptosis and phosphorylate Bcl-2 in small cell lung cancer (SCLC) (43). Beta-Lapachone,... [Pg.77]

Kasahara, K., Fujiwara, Y., Sugimoto, Y, Nishio, K., Tamura, T., Matsuda, T., Saijo, N. 1992. Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines, / Natl. Cancer Inst. 84 113-118. [Pg.8]

Irinotecan, an antineoplastic-prodrug, is widely used for the treatment of colorectal, lung and other cancers, and is one of model pharmaceuticals for personalized medicine. The active metabolite, SN-38, is a topoisomerase I inhibitor generated by hydrolysis of irinotecan by carboxylesterases. SN-38 is subsequently glucuronidated... [Pg.267]


See other pages where Topoisomerase inhibitors lung cancer is mentioned: [Pg.40]    [Pg.94]    [Pg.268]    [Pg.78]    [Pg.1146]    [Pg.861]    [Pg.794]    [Pg.794]    [Pg.171]    [Pg.101]    [Pg.152]    [Pg.554]    [Pg.297]    [Pg.432]    [Pg.1289]    [Pg.1468]    [Pg.554]    [Pg.1252]    [Pg.1469]    [Pg.35]    [Pg.35]   
See also in sourсe #XX -- [ Pg.707 ]




SEARCH



Lung cancer

Topoisomerase

Topoisomerase inhibitors

Topoisomerases

© 2024 chempedia.info