Tissue adhesives control

Quinn, J., Drzewiecki, A., Li, M., Stiell, I., Sutcliffe, T., Elmsiie, T. and Wood, W., A randomized, controlled trial comparing a tissue adhesive with suturing in the repair of pediatric facial lacerations. Ann. Emerg. Med., 22, 1130-1135 (1993). 

The poly (alkyl cyanoacrylates) have been used extensively as hemostatic and tissue adhesives. They can be polymerized under controlled... 

HA has been used in implantable medical devices for the reduction of post-surgical adhesions. One such device, Seprafilm , has been on the market for ten years and is stiU the market leader for adhesion control in general surgical applications. Solutions of HA have been shown to act as tissue protectants and have been shown to affect adhesion formation in animal models (23-26). 

Early demonstration that the absorption of poly(methoxypropyl cyanoacrylate) can be accelerated in the presence of hquid absorbable oxalate polymers led Shalaby to develop a new family of methoxypropyl cyanoacrylate (MFC)/polyester formulations as tissue adhesives with a broad range of properties. These formulations were tailored to produce absorbable tissue adhesives with a range of adhesive properties and compositionally controlled compliance depending on the type and content of the absorbable polyester component in the formulation. 

Wound healing strength of various tissue adhesives vs. corresponding controls. 

Methoxypropyl cyanoacrylate tissue adhesive (C-TA) as a positive control... 

Owing to its non-adhesive nature and slower solidification characteristics, it has been suggested that this material can be delivered in a more sustained, controllable fashion with more nidal penetration and less chance of tissue adherence to the catheter (Velat et al, 2008). However, despite less tissue adhesion, there have been reported cases of the catheter tip becoming trapped in the delivered material during Onyx delivery (Weber et al, 2007). Also, it has been argued that with greater nidal penetration, there is a potential for increased complication rates due to subsequent increased venous occlusion. 

Larval Arizona tiger salamanders (Ambystoma tigrinum nebulosum) can discriminate between kin and nonkin (Pfennig et al. 1994). In experimental tests, cannibalistic morphs may prey preferentially on unrelated individuals over related ones. The sensory basis for this discrimination was examined by covering the nares of test animals with Vetbond (3M Animal Care Products), an w-butyl cyanoacrylate tissue adhesive. This material blocks the passage of water over the nasal epithelium. In tests, some animals had their nares blocked, while sham controls had the adhesive placed between their nares. Larvae whose nares were blocked consumed kin and nonkin randomly. Animals without their nares blocked consumed more nonkin than kin. These results suggest that discrimination is based on chemical cues. 

Guidance for Industry and FDA Staff Class II Special Controls Guidance Document Tissue Adhesive for the Topical Approximation of Skin. Issued May 30, 2008. Supersedes Cyanoacrylate Tissue Adhesive for the Topical Approximation of Skin — Premarket Approval Applications (PMAs), dated February 13, 2004 (issued on July 3, 2007), contact George J. Mattamal, Ph.D., at 240-276-3619 or by email at george.mattamal fda.hhs.gov. 

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