Timeline section

The validation procedure can be subdivided, as per timeline, into three discrete task groups pre-installation, upon installation and postinstallation. The subsequent sections in this chapter will focus on each of these, defining the terms and providing a chronological progression of... 

Timelines alone do not identify the root causes of an incident. They should be used in conjunction with other tools, described in the following sections. 

Next the team develops a chronology of events based on the available known times and sequences. This document is usually referred to as a timeline. (See the detailed description of timeline development in Section 9.3.) Unconfirmed assumptions regarding chronology should be clearly identified as unconfirmed, and action should be initiated to verify assumptions. Many investigators use relatively simple timelines (instead of sequence diagrams) with the logic tree methods because the logic tree itself shows the interactions of events and conditions. 

These tasks have heen discussed previously. The following represents a brief summary, but more detail about organizing data with a timeline is provided in Section 9.3. 

Integrate your timeline, list of expected outcomes, and conclusions into a final draft ofthe Outcomes and Impacts section. Edit and proofread the section so that it is ready for peer review or final submission (see chapter 18). 

The submission project plan should identify the critical path of the application and the major milestones influencing the timeline. An index should be prepared identifying the critical sections and associated documents and the targeted availability of the documents for inclusion in the application. Systems should be in place for the controlled physical assembly of the application, including appropriate procedures for assembling the application and performing adequate quality control. Checklists are very helpful in ensuring that all necessary elements are included. 

By March 2003, OPCW inspectors had verified the destruction of approximately 7,305 tonnes of chemical agents and approximately 2 million munitions. India and the Republic of Korea are expected to meet the CWC 10-year CW destruction deadline. However, by that time, some semi-official US sources had suggested that the United States might have difficulty in meeting the 10-year timeline (see section 7). 

A timeline in each volume. This section details the chronology of the discovery of the elements. 

In terms of the amount of drug product to be set up, a later-stage study requires approximately 100 tablets (solid) or 1 L (solution). Early-stage work requires approximately 25 tablets (solid) or 50 ml (solution). As outlined in Section II.B, the typical length of a study is approximately 6 weeks. This can be reduced by a factor of 2 for early-stage work (phase I clinical trials) where timelines can be extremely tight. 

Chapters 2 -6 describe the status of the IMPROVE project after the third project cycle. This description, for simplicity reasons and for giving a clear view on the scientific outcome, is organized along the corresponding subprojects of IMPROVE, essentially one section per subproject. This section collects the results of the first three cycles of an IMPROVE subproject, if the results are not overridden by later results. So, the book is not structured along the timeline. Instead, it is structured along results for specific topics elaborated by subprojects. 

In the following sections, important steps in the monitoring process will be discussed in more detail, including evaluation of experiments and their data, impact of experiment failures on timelines, communication of changes in personnel and schedule on either side, and changes in the scope of the agreed-upon transfer work. 

Within each category are several specific activities listed as examples. The sponsor may list as many specific activities as appropriate for the study. For each activity the sponsor should indicate whether that activity will be the sponsor s responsibility or the CRO s responsibility by placing a check in the appropriate column. In those cases where the sponsor feels that the activity will be shared with the CRO, sponsors should examine the activity to determine whether it could be broken down into more discrete items. This will minimize confusion over who actually is responsible for the activity. The last section of the study specifications worksheet is entitled Project Timeline. It contains the sponsor s projected dates for completion of study milestones. Twenty-six suggested milestones are listed the sponsor may wish to modify the list according to its own milestones. 

Pterin-inspired models have evolved in response to the acquisition and interpretation of new data from Moco, both from holoenzymes and from dissociated, isolated Moco samples. The key events punctuating the growing knowledge of the nature of the pterin in Moco were described in the preceding section and are graphically presented as a timeline in Figure 2.8. The development of pterin models can be appreciated and understood when compared to this timeline. For the purposes of this chapter, the pterin model evolution presented below is partitioned into three sections, described as three generations of models. 

The vast majority of MoHM studies have targeted active site (1) or components thereof. A timeline representing important developments in this area is presented in Figure 7.5 (see Sections 7.3.1-7.3.3 for background). 

A timeline is made up of a sequence of events arranged in chronological sequence, thus providing a clear picture of causes and their effects. Timelines generally comprise three major sections. 

Step 1. Define project. In this step, the market opportunities are identified, a design team is assigned, and resources are allocated. Typically, the project timeline is summarized in a Gantt chart (see Section 12.4). 

Figure 9.1 Selected milestones that mark the path of humankind s cultural and technological progress and the way we live today. The authors acknowledge that there is stUl fiery debate about the exact age of the earth and many aspects of the early parts of recorded human history. Therefore, the early steps of the timeline depicted in this diagram are not meant to express a definitive outcome of conflicting viewpoints rather, they are included as part of the Kennedy metaphorical time capsule used in Section 9.3.

---