Thyroxine tablets

C) thyroxine tablets should be prescribed and taken regularly by the patient... 

Fig. 3 Biochemical monitoring of a patient during treatment for thyroid disease. This 55-year-old woman was first diagnosed as hyperthyroid, and received radioiodine therapy. She became profoundly hypothyroid, and was treated with thyroxine. Her thyroid hormone results at first indicated good replacement, but recently they indicate that she Is under replaced. It is possible that she Is not taking her thyroxine tablets regularly.

A woman whose thyroid gland was surgically removed was treated with 0.10 mg of thyroxine/daily (tablet form). After 3 months of treatment, her serum TSH levels were constant at 6.0 MlU/ml (reference range = 0.3—5.0 MlU/ml). She complained of fatigue, weight gain, and hoarseness. Her dose of thyroid hormone should... 

Levothyroxine Synthroid, Levothroid, and other generics 25-, 50-, 75-, 88-, 100-, 112-, 125-, 137-, 150-, 1 75-, 200-, 300-mcg tablets 200-and 500-mcg/vial injection Levoxyl, Thyro-Tabs, Unithroid Synthetic T4 50-60 meg Stable predictable potency generics are bioequivalent when switching from natural thyroid to t-thyroxine, lower dose by 1/2 grain variable absorption between products half-life = 7 days, so daily dosing considered to be drug of choice... 

In an open label study, patients with a basal thyroid-stimulating hormone (TSH) value less than 1.0 mU/1 and hyperthyroidism-associated symptoms were administered one tablet containing 20 mg of European bugleweed daily for approximately 15 weeks. In treated patients, an increase in urinary thyroxine (T ) excretion was observed, along with a reduction in symptoms related to hyperthyroidism, notably, a reduction in heart rate in the morning. In this study, European bugleweed was generally well tolerated, with only minor adverse events reported in the study. Of these, only one adverse event, subjective "disturbances of the cardiac rhythm," was reported after 7 weeks of treatment (Beer et al. 2008). 

Despite the fact that a biological method is the only way to obtain a reliable estimate of the potency of thyroid, chemical assessment is still quite frequently required. The B.P, method is a determination of so-called iodine in combination as thyroxine and is based on the observations of Harington and Randall that, after hydrolysis of the thyroid with sodium hydroxide, an acid-insoluble fraction can be separated which consists essentially of thyroxine. There have always been mechanical difficulties associated with this assay, especially when an attempt is made to apply it to formulated products such as tablets. Further considerations, however, indicate that it is an unreliable guide to the potency of thyroid. Firstly, the discovery of the highly potent 3,5,3 -tri-iodothyronine (liothyronine) invalidates the assumption that the amount of total iodine in the acid-insoluble fraction is related to the proportion of thyroxine and hence to potency secondly it has been shown that when lactose is present during the hydrolysis stage a greater proportion of iodine is present in the subsequent acid-precipitated fraction than if the lactose is absent. This observation was first made by Doery and has since been confirmed in a... 

Tablets of Thyroxine Sodium, B.P. Usually contain 0-05 mg. These tablets contain too much organic matter for application of the flask-combustion method.

Weigh an amount of powdered tablets equivalent to about 1-5 mg of thyroxine sodium into a nickel crucible about 6 mm in diameter and about 6 mm deep and add 3 ml of water followed by 5 g of sodium hydroxide in small pieces. Heat on a water-bath to remove the water, add a further 4 g of sodium hydroxide and heat over a Bunsen flame, at first gently and then sufficiently strongly to maintain the mixture in a... 

Adamson et alM recommended a colorimetric method based upon nitrosation for the determination of small amounts of thyroxine. Extraction of thyroxine from tablets for this method presents little difficulty most of the commonly used excipients are either soluble in the reagents without interfering or can be removed by some simple extraction and filtration technique. 

In conclusion, the study indicates that the three types of therapy for endemic goitre are equally effective, provided the patients receive a sufficient quantity of iodine. The form of iodine administration, whether as iodide or as L-Thyroxine, is not important except for compliance, which is best when the patient takes only one tablet per day. 

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