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Thyroid growth control

There are a number of possibilities that could account for the interaction between thyroid hormone and NGF. For example, treatments with insulin and insulin-like growth factor II have been found to increase specific and saturable NGF binding sites in cultured human neuroblastoma cells.It is possible that analogous mechanisms between thyroid hormone and NGF may operate in subcortical cholinergic cells. Another possibility could be that if thyroid hormone controls the formation of ChAT or of proteins essential for cholinergic cell maturation at a pretranslational level S and NGF regulates the de novo synthesis of these crucial proteins at transcriptional level,30 then a combination of these effects could synergistically potentiate ChAT activity. [Pg.144]

The original assumption about goitrogenesis in iodine deficiency was that the lack of iodine decreased thyroid hormone production, thereby causing an increase in TSH, which would stimulate thyroid growth. Hhile many subjects in iodine deficiency areas do not have abnormally elevated TSH levels, their,mean serum TSH concentration is higher that that in a non iodine deficient control population. This difference is especially... [Pg.62]

The thyroid gland, located in the base of the neck, exerts i key role on growth and metabolism. In contrast with that of some of the other endocrine glands, this control is effected Ihrough a pair of relatively simple molecules, thyroxine, and its close congener, triiodothyronine. Cases of thyroid deficien-cy (hypothyroidism) are common enough to warrant the production... [Pg.95]

The growth and spread of thyroid carcinoma are stimulated by TSH. An important component of thyroid carcinoma management is the use of LT4 to suppress TSH secretion. Early in therapy, patients receive the lowest LT4 dose sufficient to fully suppress TSH to undetectable levels. Controlled trials show that suppressive LT4 therapy reduces tumor growth and improves survival. [Pg.668]

This hormone controls the growth and activity of the thyroid gland. It influences... [Pg.270]

The thyroid and parathyroid glands serve a number of vital endocrine functions. The thyroid gland synthesizes and secretes the thyroid hormones T3 and T4. These hormones are important regulators of cellular metabolism and metabolic rate. Thyroid hormones also interact with other hormones to facilitate normal growth and development. The parathyroid glands control calcium homeostasis through the release of PTH. This hormone is crucial... [Pg.472]


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See also in sourсe #XX -- [ Pg.35 , Pg.452 ]




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