Potentiation synergists

These drug s are contraindicated in those with a known hypersensitivity to any component of the preparation. The topical anesthetics are used cautiously in patients receiving Class I antiarrhytiimic drug s such as tocainide and mexiletine because the toxic effects are additive and potentially synergistic. 

Interactions may take place in the toxicokinetic phase and/or in the toxicodynamic phase. The interactions may result in either a weaker (antagonistic) or stronger (potentiated, synergistic) combined effect than would be expected from knowledge about the toxicity and mode of action of each individual compound. 

In retrospect, it is likely that for many substances the uncertainties could be considerably greater and probably toward the lower risk side, given the design and intent of the conservative calculation model On the other hand, lack of definitive information on potential synergistic or additive interactions could lead to a reason to take this more conservative approach. 

A case report with a review of 27 cases of thromboembolic events after the administration of intravenous globulin with or without glucocorticoids has been published (492). The authors suggested that this combined therapy should be administered with caution because of its potential synergistic thrombotic risk. 

Hyalurunidase, however, acted only on the nucleus pulposus and was regarded as a potential synergistic drug for chemonucleolysis. 

Duquesne, S., Lefebvre, J., Bourbigot, S., Le Bras, M., Delobel, R., and Recourt, P. 2004. Nanoparticles as potential synergists in intumescent systems. Paper Presented at the ACS 228th Fall National Meeting, Division of Polymeric Materials, Science and Engineering, Session—Fire and Materials, Philadelphia, PA. 

In 2003, Krane et al. used a functional assay, microphysiometry, to evaluate the effects of ginkgolides on the human PAF receptor. GB and lO-O-benzyl-GB showed 81% and 93% (100-pM concentration) inhibition, respectively, of the PAF receptor response, the latter being equivalent to the effect of WEB2086. G. biloba extract mixtures were also tested, which indicated potential synergistic effects among the components in the extract. 

The synthesis, through copolymerization routes, of polymeric systems bearing on the same macromolecule different photosensitive groups may provide potential synergistic effects of activity. 

If AmB is to be used in conjunction with another nephrotoxic agent, several measures can be taken in order to minimize the potential synergistic toxicity of amphotericin B. For example, if an aminoglycoside or cyclosporine is to be used, monitoring of their serum concentrations will help avoid toxic levels. It is also imperative to evaluate electrolyte losses closely and be aggressive in their replacement, since cyclosporine A nephrotoxicity may be exacerbated by dehydration [221], and to follow magnesium levels closely since... 

Maciver, D.K, (1966). The development of Tmpital, a poly alkoxy acelal of pi peron aldehyde as a potential synergist for pyrethrins. Pyrellmim Pc>stS, 3-6,... 

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