Preoperative chemoradiation

VlLLAFRANCA E, OKRUZHNOV Y, DOMIN-guez MA et al. Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 2001 19 1779-1786. 

Yoon W-H, Choi J-H, Kim J-R, et al. Enhanced Tumoricidal Effect of Preoperative Chemoradiation Using Capecitabine for Locally Advanced Rectal Cancer. ASCO 2001, 104b. 

Postoperative Radiation Therapy Postoperative Chemotherapy or Chemoradiation NeOADJUVANT THERAPY, In GENERAL Preoperative Radiation Therapy Preoperative Chemotherapy Preoperative Chemoradiation... 

With a median follow-up of 8.2 yr, neoadjuvant therapy did not improve survival over surgery alone. Median survival was 17.6 vs 16.9 mo. Three-year survival was 16% for surgery only vs 30% for preoperative chemoradiation (p = 0.15). Multivariate analysis showed a survival benefit to neoadjuvant therapy (p = 0.09). There was also a significant... 

Urba SG, Orringer MB, Turrisi A, Iannettoni M, Forastiere A, Strawderman M. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 2001 19(2) 305-313. 

Forastiere AA, Orringer MB, Perez-Tamayo C, Urba SG, Zahurak M. Preoperative chemoradiation followed by transhiatal esophagectomy for carcinoma of the esophagus final report. J Clin Oncol 1993 11(6) 1118—1123. 

Because surgical resection is the only curative treatment modality, several clinical trials have been carried out to improve the success of gastric cancer. Furthermore, prompted by the promising results and acceptable toxicity of preoperative chemoradiation... 

In a nonrandomized trial, Spitz et al. (50) compared the preoperative chemoradiation approach with standard adjuvant chemoradiotherapy. Preoperative radiotherapy was delivered either in the standard regimen of 50.4 Gy over 5.5 wk or at 30 Gy as rapid fractionation over 2 wk postoperative irradiation was given up to a total dose of 50.4 Gy in standard fractionation. Both preoperative and postoperative radiotherapy were delivered concurrently with a continuous infusion 5-FU at 300 mg/m2/d for 5 d weekly. At a median follow-up of 19 mo, patients who underwent preoperative and postoperative chemoradiation had similar treatment toxicity, patterns of recurrence, and survival. 

Recent preoperative chemoradiation studies of resectable pancreatic cancer have demonstrated improved survival. One of the first of these evaluated preoperative therapy using 50.4 Gy standard fractionation irradiation with a concurrent continuous infusion of low-dose 5-FU in patients having resectable pancreatic adenocarcinoma (52). The recurrence rate and median survival duration were better than those historically reported for patients only undergoing pancreatoduodenectomy (53). These findings prompted further studies evaluating the role of preoperative chemoradiation in patients having resectable pancreatic cancer. Data on 132 consecutive patients who received preoperative 5-FU and... 

Staley CA, et al. Preoperative chemoradiation, pancreaticoduodenectomy, and intraoperative radiation therapy for adenocarcinoma of the pancreatic head. Am J Surg 1996 171 (1) 118-124 discussion 124-125. 

Pisters PW, et al. Preoperative chemoradiation for patients with pancreatic cancer toxicity of endobiliary stents. J Clin Oncol 2000 18(4) 860-867. 

Resectability, Pathologic Response Rates, and Survival Following Preoperative Chemoradiation Therapy Regimens... 

Janjan NA, Khoo VS, Abbruzzese J, et al. Tumor downstaging and sphincter preservation with preoperative chemoradiation in locally advanced rectal cancer the M. D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 1999 44(5) 1027-1038. 

Valentini V, Coco C, Cellini N, et al. Preoperative chemoradiation for extraperitoneal T3 rectal cancer acute toxicity, tumor response, and sphincter preservation. Int J Radiat Oncol Biol Phys 1998 40 1067-1075. 

F.A. Calvo, M. Domper, R. Matute, R. Martinez-Lazaro, J.A. Arranz, M. Desco, E. Alvarez, J.L. Carreras, F-FDG positron emission tomography staging and restaging in rectal cancer treated with preoperative chemoradiation, Int. J. Radiat. Oncol. Biol. Phys. 58(2) (2004) 528-535. 

B. D. Minsky, L. Saltz, W.D. Wong, S. Larson, Sequential preoperative fluorodeox-yglucose-positron emission tomography assessment of response to preoperative chemoradiation A means for determining longterm outcomes of rectal cancer, J. Am. Coll. Surg. 199(1) (2004) 1-7. 

Evans DB. Preoperative chemoradiation for pancreatic cancer. Semin Oncol. 2005 32(suppl 9) S25-S29. 

Glaser CM, Millesi W, Kornek GV, Lang S, Schull B, Watzinger F, Selzer E, Lavey RS. Impact of hemoglobin level and use of recombinant erythropoietin on efficacy of preoperative chemoradiation therapy for squamous cell carcinoma of the oral cavity and oropharynx. Int J Radiat Oncol Biol Phys 2001 50(3) 705-15. 

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