Thiocarbamide

Although in the dry state carbon tetrachloride may be stored indefinitely in contact with some metal surfaces, its decomposition upon contact with water or on heating in air makes it desirable, if not always necessary, to add a smaH quantity of stabHizer to the commercial product. A number of compounds have been claimed to be effective stabHizers for carbon tetrachloride, eg, alkyl cyanamides such as diethyl cyanamide (39), 0.34—1% diphenylamine (40), ethyl acetate to protect copper (41), up to 1% ethyl cyanide (42), fatty acid derivatives to protect aluminum (43), hexamethylenetetramine (44), resins and amines (45), thiocarbamide (46), and a ureide, ie, guanidine (47). 

Aryl-substituted thiourea derivatives (thiocarbamide derivatives) [4] ... 

The reaction is carried out in both acidic and basic media. Thus, for example, the interaction of 4-diethylaminobut-3-en-2-one with thiocarbamide is performed at 75°C for 30 h (EtOK, EtOH) to result in 54% yield of the major product. The existence of two tautomers 274 and 275 was proved for 2-mercapto-4-methylpyrimidine (Y = S) by IR and H NMR spectroscopy (76ZOR2063). 

Aliphatic polyamine disulfides—imino-, carbamide-, thiocarbamide-, ethylenediamine------are low-effi-... 

Figure 1 Thermal oxidative breakdown of polyethylene (temperature 200°C P02 = 350 Tor stabilizer concentration 0.5 mass percent). 1-without stabilizer 2-CaO-6 3-polydii-minodiphenylmethane disulfide 4-polydiiminodiphenylsul-fon disulfide 5-polyparaoxydiphenylamine disulfide 6-po-lydimethylaniline disulfide 7-polyaniline disulfide 8-polydiiminodiphenyloxide disulfide 9-polythiosemicarbaz-ide disulfide 10-polyamine disulfide 11-polycarbamide disulfide 12-poly thiocarbamide disulfide 13-polyethylenedi-amine disulfide.

Hydrochloric acid/thiourea [thiocarbamide, CS(NH2)2], The procedure for cleaning iron oxides containing copper and copper oxides is the same as for cleaning iron oxides alone. A typical formulation is 5% HC1 with 2% thiourea, plus corrosion inhibitor, wetting agent, and antifoam. A complete removal of copper is required because the passivation process otherwise will not be effective. 

Tetrahydrocannabinol (= THC)-11-carboxylic acid 290 Tetrahydrocortiso 221 Tetrahydrocortisone 221 Tetrahydrosteroids 222 Tetrazolium salts, reduction 61 Thalidomide 45 -, hydrolysis products 45 Thiabendazole 307, 308 Thiamine 235, 236, 397 Thickening agents 179 Thin-layer chromatography, advantage 5 -, numbers of publications per year 6 Thiobarbiturates 45,66 Thiocarbamide derivatives 322 Thiocarbamides, N -ary I-N -benzenesulfo-nyl- 248,249 Thiochrome 395... 

Kim YM, Ziegler DM. Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1. Drug Metab Dispos 2000 28 1003-6. 

Just as a multiplicity of hydroxyl groups is normally related to sweetness, multiple nitro groups and the sulfur atom in the —S—S— or —C=S— linkage have been associated with bitter taste. Thus, it was obseiwed that a compound containing three nitro groups, such as picric acid, is usually bitter, and that those with two nitro group may be bitter. Compounds having structure A are also frequently bitter, and it was deduced that the bitterness of the acyl-thiocarbamide class of compounds is due to structure B. 

Phenyl thiocarbamide, pi58 a-Phenyl-o-tohiic acid, b84 Phenyl m-tolyl ether, p76 Phloroglucinol, t318 Phorone, d613 Phthalaldehydic acid, 37... 

Stevens GJ, Hitchcock K, Wang YK, et al. In Vitro metabolism of N-(5-Chloro-2-methylphenyl)-N-(2-methylpropyl)thiourea species comparison and identification of a novel thiocarbamide-glutathione adduct. Chem Res Toxicol 1997 10 733-741. 

The thiocarbamide adducts 209, readily obtained from the corresponding 1,3-amino alcohols, can be cyclized to d -fused 2-iminotetrahydrothiazines... 

A number of substituted derivatives of 305 (cis, n = 1, 2 trans, n = 2), 306 cis or trans), 307, and 308 diendo and diexo) (R = Me, Et, Ph, substituted aryl) were prepared from the corresponding amino acids with isothiocyanate and acidic ring closure of the resulting thiocarbamide... 

In 1884, Emerson-Reynolds reported deposition of PbS films by reaction between thiourea (thiocarbamide) and alkaline lead tartrate, where the metallic sulphide. .. became firmly attached as a specular layer to the sides of the vessel [6], A wide range of substrates, apart from that just mentioned (a glass beaker), was successfully used for this deposition porcelain, ebonite, iron, steel, and brass were specifically mentioned. Even more important, the deposits were very adherent, as quantified by their ability to withstand considerable friction with a wash-leather, and under this treatment take a fine polish. ... 

These are the most important of the antithyroid drugs. The main compounds are propyittiiouracii, carbimazoie, and its active metabolite, methimazoie. They all contain a thiocarbamide... 

The chemical structures of these compounds are shown in Figure 38-5. The thiocarbamide group is essential for antithyroid... 

Structure of thioamides. The thiocarbamide moiety is shaded in color. 

Complexes [NbCULJCl, where L = RNHCSNHpy, were obtained 150 their IR spectra indicate bidentate behavior of L via sulfur and the heterocyclic nitrogen they exhibit semiconductor properties. Similar behavior and properties were reported for the adducts formed with N, N -diaryl-substituted formamidino-AP -aryl-substituted carbamides and thiocarbamides. 

As carbamic acid and carbamide are related to carbonic acid, so are thioearbamic acid and thiocarbamide related to thiocarbonic acid ... 

Thiocarbonic Acid. Dithiocarbamic Acid, or Thiolthioncarbamic Acid. Thiocarbamide. 

Thiocarbamide or Thiourea, CS(NH2)a, is formed by heating ammonium thiocyanate to 140° C., when it undergoes an intramolecular rearrangement 3... 

Another method of preparation consists in heating carbon disulphide with ammonium carbonate in a sealed tube. The other product of this reaction is ammonium thiocyanate. The yield of thiocarbamide by this method is stated to be much below the theoretical value.6... 

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