Human flavin-containing monooxygenase

Kim YM, Ziegler DM. Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1. Drug Metab Dispos 2000 28 1003-6. 

Cashman JR, Zhang J. Interindividual differences of human flavin-containing monooxygenase 3 genetic polymorphisms and functional variation. Drug Metab Dispos 2002 30(10) 1043-1052. 

Cashman JR, Xiong YN, Xu L, et al. N-oxygenation of amphetamine and methamphetamine by the human flavin-containing monooxygenase (form 3) role in bioactivation and detoxication. J Pharmacol Exp Ther 1999 288(3) 1251—1260. 

Using pig and human microsomes and cDNA-expressed human flavin-containing monooxygenase, Lin and Cashman demonstrated a metabolic detoxification pathway that converts tyramine into the HA derivative, 20, and the anti oxime, 21, which was sufficiently stable to permit its chemical characterization". ... 

Cashman JR, Zhang J. Human flavin-containing monooxygenases. Annu Rev Pharmacol Toxicol 2006 46 65-100. 

Cashman JR. Human flavin-containing monooxygenase (form 3) Polymorphisms and variations in chemical metabolism. Pharmacogenomics 2002 3 325-39. 

Cashman, J. R. (2000) Human flavin-containing monooxygenase substrate specificity and role in drug metabolism. Curr. Drug Metab. 1,1037-1045. 

Hisamuddin, I. M. and Yang, V. W. (2007) Genetic polymorphisms of human flavin-containing monooxygenase 3 implications for drug metabolism and clinical perspectives. 

Itagaki, K., Carver, G.T. andPhilpot, R.M. (1996) Expression and characterization ofa modified flavin-containing monooxygenase 4 from humans. The Journal of Biological Chemistry, 271, 2012—20107. 

Hamman MA, Haehner-Daniels BD, Wrighton SA, et al. Stereoselective sulfoxidation of sulin-dac sulfide by flavin-containing monooxygenases. Comparison of human liver and kidney microsomes and mammalian enzymes. Biochem Pharmacol 2000 60(1) 7-17. 

Tam TW, Liu R, Amason IT et al (2009) Actions of ethnobotanicaUy selected Cree antidiabetic plants on human cytochrome P450 isoforms and flavin-containing monooxygenase 3. 1 Ethnopharmacol 126 119-126... 

Koukouritaka SB, Simpson P, Yeung CK, Rettie AE, Hines RN (2002) Human hepatic flavin-containing monooxygenase 1 (FMOl) and 3 (FM03) developmental expression. Pediatr Res 51 236-243... 

Cashman JR, Park SB, Berkman CE, Cashman LE. Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. Chem Biol Interact 1995 96 33-46. 

Teyssier C, Guenot E, Suschetet M, Siess MIT. Metabolism of diallyl disulfide by human liver microsomal cytochromes P-450 and flavin-containing monooxygenases. Drug Metab Dispos 1999 27 835-841. 

Nnane IP, Damani LA. Involvement of cytochrome P450 and the flavin-containing monooxygenase(s) in the sulphoxidation of simple sulphides in human liver microsomes. Life Sci 2003 73 359 369. 

Overby LH, Buckpitt AR, Lawton MP, Atta-Asafo-Adjei E, Schulze J, Philpot RM. Characterization of flavin-containing monooxygenase 5 (FM05) cloned from human and guinea pig evidence that the unique catalytic properties of FM05 are not confined to the rabbit ortholog. Arch Biochem Biophys 1995 317 275-284. 

Overby LH, Carver GC, Philpot RM. Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. Chem Biol Interact 1997 106 29-45. 

Krause, R.J., Lash, L.H., and Elfarra, A.A. (2003) Human kidney flavin-containing monooxygenases (FMOs) and their potential roles in cysteine S-conjugate metabohsm and nephrotoxicity. J. Pharmacol. Exp. Ther. 304,185-191. 

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