Thermosensitive hydrogels

Permeability control of solutes through thermosensitive hydrogel membranes may be thought of in terms of the degree of hydration and kinetics of... 

These thermosensitive hydrogels were utilized for the loading of heparin... 

YH Bae, T Okano, SW Kim. Insulin permeation through thermosensitive hydrogels. J Controlled Release 9 271-279, 1989. 

A Gutowska, YH Bae, SW Kim. Heparin release from thermosensitive hydrogels. J Controlled Release 22 95-99, 1992. 

Thermosensitive hydrogels, 13 743 THERMOSET Thermoset recycling pyramid, 13 780-781 Thermoset elastomers, 20 71 Thermoset epoxy resins, curing of, 10 421 Thermoset flexible polyurethane foams properties of, 25 461 Thermoset matrix composites, 21 456 Thermo set molding properties of diallyl isophthalate, 2 262t Thermoset polymers, 25 455 cured, 10 425... 

Wu J, Wei W, Wang LY, Su ZG, Ma GH (2007) A thermosensitive hydrogel based on quatemized chitosan and polyethylene glycol) for nasal drug delivery system. Biomaterials 28 2220-2232. 

Tatykhanova GS, Kudaibergenov SE. (2008) Controlled release of local anesthetic drug richlocaine from the pH- and thermosensitive hydrogels-copolymers of N-isopropylacrilamide and acrylic acid. New smart materials via metal mediated macromolecular engineering from complex to nanostructures. Antalya, Turkey, 1-12 September 2008. 

Clinical applications of thermosensitive hydrogels based on NIPAAm and its derivatives have limitations [121], The monomers and cross-linkers used in the synthesis of the hydrogels are still not known to be biocompatible and biodegradable. The observation that acrylamide-based polymers activate platelets upon contact with blood, together with the unclear metabolism of poly(NIPAAm), requires extensive toxicity studies before clinical applications can merge. 

Makino, K. Fujita, Y. Takao, K. Kobayashi, S. Ohshima, H. Preparation and properties of thermosensitive hydrogel microcapsules. Colloids Surf. B Biointerf. 2001, 21, 259-263. 

Among stimuli-responsive or thermoresponsive polymer microspheres, poly(N-isopropylacrylamidc) (PNIPA) was investigated most intensively. Cross-linked PNIPA is a thermosensitive hydrogel which undergoes a volume phase transition at its lower critical solution temperature (LCST) of around 34 °C. Several authors reported the synthesis of PNIPA microspheres [68-73]. 

Eddington DT, Beebe DJ (2004b) A valved responsive hydrogel microdispensing device with integrated pressure source. J Microelectoromech Sys 13 586-593 Feil H, Bae Y, Feijen J, Kim S (1991) Molecuar separation by thermosensitive hydrogel membranes. J Membr Sci 64 283-294... 

Harmon ME, Tang MF (2003) A microfluidic actuator based on thermosensitive hydrogels. Polymer 44 4547 556... 

Arakawa T, Shlrasakl Y, Aokl T, Funatsu T, Shoji S (2007) Three-dimensional sheath flow sorting microsystem using thermosensitive hydrogel. Sens Actuators A 135 99-105... 

H. Feil, Y.H. Bae, J. Feijen and S.W. Kim, Molecular separation by thermosensitive hydrogel membranes, J. Membr. Sci., 1991, 64, 283 N. Kyaman, D. Kazan, A. Eearslan, O. Okay and B.M. Baysal, Structure and protein separation efficiency of poly(Y-isopropylacrylamide) gels Effect of synthesis conditions, J. Appl. Polym. Sci., 1998, 67, 805. 

K. Suwa, Y. Wada, A. Kishida and M. Akashi, Synthesis and functionalities of poly(jV-vinylalkylamide). VI. A novel thermosensitive hydrogel cross-linked poly(/V-vinylisobutyramide), J. Polym. Sci., Polym. Chem. Ed., 1997, 35, 3377. 

Liu, Z.S. S.Z. Erhan. Soy-Based Thermosensitive Hydrogels for Controlled Release Systems. U.S. Patent Application 20070077298 (2007). 

Lee P Y, Li Z, Huang L (2003). Thermosensitive hydrogel as a Tgf-betal gene delivery vehicle enhances diabetic wound healing. Pharm. Res. 20 1995-2000. 

Bhattarai N, Ramay FIR et al (2005) PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release. J Control Release 103 609-624... 

Bae YH, Okano T, Kim SW. On-off thermocontrol of solute transport. II. Solute release from thermosensitive hydrogels. Pharm Res 1991 8 624 628. 

Feil H, Bae YH, Feijen J, Kim SW. Mechanism of solute diffusion in thermosensitive hydrogels. In Proceedings of the 18th International Symposium on the Controlled Release of Bioactive Materials Lee VHL, Ed CRC Inc Lincolnshire, IL, 1991 142. 

Jeong B, Bae YH, Kim SW. Drug release from hiodegradahle injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J Contr Rel 2000 63 155-163. 

Mukae, K., Bae, Y.H., Okano, T. et al. 1990a. A new thermosensitive hydrogel Polyfethylene oxide-dimethylsiloxane-ethylene oxide)/poly(N-isopropylacrylamide) interpenetrating polymer networks, n. On-off regulation of solute release. Polym 7. 22 250-265. 

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