Sustained release of protein

Langer, R. and Folkman, J. (1976). Pol3miers for the sustained release of proteins and other macromolecules. Nature 363, 475 82. 

Lee, J. B., Yoon, J. J., Lee, D. S. Park, T. G. (2004) Photo-crosslinkable, thermosensitive and biodegradable Pluronic hydrogels for sustained release of protein. Journal of Biomaterials Science - Polymer Edition, 15, 1571-1583. 

Utility of collagen for sustained release of protein drugs was demonstrated by Weiner et al. (1985), who reported that enhanced retention of intramuscularly administered human growth hormone was measured in rats, upon incorporation of liposomal hormone in a dilute collagen gel. Increased duration of serum insulin levels in diabetic rats occurred with insulin-containing liposomes entrapped in 0.9% collagen, relative to liposomal insulin alone. Hori et al. (1989) showed that subcutaneous injection of insulin in a collagen gel increased plasma levels in rats (over a... 

Use of cholesterol pellets for sustained release of protein antigens was recently examined by Opdebeeck and Tucker (1993). Utilizing matrices... 

Glycol chitosan modified by 5p-cholanic acid NPs For the sustained release of proteins during murine embryonic limb skeletogenesis [161]... 

Li T, Longobardi L, Granero-Molto F, Myers TJ, Yan Y, SpagnoU A. Use of glycol chitosan modified by 5p-cholanic acid nanoparticles for the sustained release of proteins during murine embryonic limb skeletogenesis. J Control Release. 2010 144(l) 101-8. 

Agarwal P, Rupenthal ID. Injectable implants for the sustained release of protein and peptide drugs. Drug Discov Today 2013 18 337-49. 

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