Therapeutic agents albumin

Rothschild et al.109 found that the addition of tryptophan to isolated perfused livers of rabbits treated with CC14 aided in the recovery of albumin synthesis. This study is consistent with the findings that tryptophan had a beneficial effect on hepatic polyribosomes and protein synthesis in rats treated with CC14. Thus, tryptophan may be a useful therapeutic agent for the livers of experimental animals injured with CC14. 

Heterodifunctionalized dendrimer-like PEOs carrying 16 hydroxyl groups at their periphery, and one aldehyde group at their focal point, have been synthesized up to the fourth generation [58]. Such a bouquet-type dendritic scaffold based on PEO can accommodate proteins such as albumin at the core, and therapeutic agents at their periphery. In this case, a protected aldehyde dihydroxyl compound has been used as the initiator for ROP. 

Albumin is an attractive macromolecular species to prepare pharmaceutical carriers used for the sustained delivery of therapeutic agents since this protein is biodegradable, bio-compatible, non-toxic, and non-immunogenic. Chemical groups susceptible to radical pol5mierization were introduced onto... 

Monoclonal antibodies for in vivo use Cytokines (e.g. interferons and interleukins) Therapeutic enzymes Thrombolytic agents Hormones Growth factors Additional miscellaneous proteins Blood Blood proteins (e.g. albumin and blood factors) Vaccines Cell- and tissue-based products Gene therapy products Antitoxins, venoms and antivenins Allenergic extracts... 

Mechanism of Action An antipsychotic agent that provides partial agonist activity at dopamine and serotonin (S-HTj ) receptors and antagonist activity at serotonin (5-HTja) receptors. Therapeutic Effect Diminishes schizophrenic behavior. Pharmacokinetics Well absorbed through the GI tract. Protein binding 99% (primarily albumin). Reaches steady levels in 2 wk. Metabolized in the liver. Eliminated primarily in feces and, to a lesser extent, in urine. Not removed by hemodialysis. Half-life 75 hr. 

Mechanism of Action An antiulcer agent that forms an ulcer-adherent complex with proteinaceous exudate, such as albumin, at ulcer site. Also forms a viscous, adhesive barrier on the surface of intact mucosa of the stomach or duodenum. Therapeutic Effect Protects damaged mucosa from further destruction by absorbing gastric acid, pepsin, and bile salts. 

Polymer nanoparticles including nanospheres and nanocapsules (Fig. 1) can be prepared according to numerous methods that have been developed over the last 30 years. The development of these methods occurred in several steps. Historically, the first nanoparticles proposed as carriers for therapeutic applications were made of gelatin and cross-linked albumin. Then, to avoid the use of proteins that may stimulate the immune system and to limit the toxicity of the cross-linking agents, nanoparticles made from synthetic polymers were developed. At first, the nanoparticles were made by emulsion polymerization of acrylamide and by dispersion polymerization of methylmethacry-late.f These nanoparticles were proposed as adjuvants for vaccines. However, since they were made of non-biodegradable polymers, these nanoparticles were rapidly substituted by particles made of biodegradable... 

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