T cell vaccination

Yoshikawa T, Okada N, Oda A et al (2008) Nanoparticles built by self-assembly of am phiphilic poly(y-glutamic acid) can deliver antigens to antigen-presenting cells with high efficiency Anew tumor-vaccine carrier for eliciting effector T cells. Vaccine 26 1303-1313... 

As opposed to the development of vaccines that produce antibodies, the development of T-cell vaccines is a novel concept. These vaccines are designed to induce primarily T-cell responses that will control the viral proliferation and viral levels during the early stages of infection and will delay the disease progression. These vaccines will not prevent infection but will inhibit HIV levels and protect uninfected memory CD4+ T cells. It is expected that HIV-infected patients receiving this vaccine may remain disease-free for a prolonged period of time. A number of current HIV vaccine trials have focused on CD8+ cell-mediated products that... 

Anti-idiotypic and antiergotypic Treg cells are activated after T-cell vaccination and are regulators of the immune response. The Treg cells induced by activated... 

Cohen IR, Quintana FJ, Mimran A. 2004. Tregs in T cell vaccination Exploring the regulation of regulation. J Clin Inv. 114 1227-1232. 

Hong J, Zang YC, Nie H, Zhong J. 2006. CD 4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis, PNAS. 103 5024-5029. 

Keywords Adaptive iimnunity Copolymer-1 (Copaxone or gladramer acetate) Immune boost Immune modulation Immune suppression Mucosal tolerance Nasal tolerance Oral tolerance T cell vaccination Vaccination... 

Bonifaz LC, Bonnyay DP, Charalambous A, Darguste DI, Fujii S, Soares H, Brimnes MK, Moltedo B, Moran TM, Steinman RM. In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J Exp Med 2004 199(6) 815-824. 

YEWDELL JW. Designing CD8-I-T cell vaccines it s not rocket science (yet). Curr Opin Immunol 2010, 22,402-410. 

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