Theory and Instrumentation of Mass Spectrometry

The theory and instrumentation of Fourier transform mass spectrometry (FTMS) have been discussed extensively in this book and elsewhere [21-23]. All experiments were performed on a Nicolet prototype FTMS-1000 Fourier transform mass spectrometer previously described in detail [24] and equipped with a 5.2 cm cubic trapping cell situated between the poles of a Varian 15 in. electromagnet maintained at 0.85 T. The cell was constructed in our laboratory and utilizes two 80 transmittance stainless steel screens as the transmitter plates. This permits irradiation with a 2.5 kW Hg-Xe arc lamp, used in conjunction with a Schoeffel 0.25 m monochromator set for 10 nm resolution. Metal ions are generated by focusing the beam of a Quanta Ray Nd YAG laser (either the fundamental line at 1064 nm or the frequency doubled line at 532 nm) into the center-drilled hole (1 mm) of a high-purity rod of the appropriate metal supported on the transmitter screen nearest to the laser. The laser ionization technique for generating metal ions has been outlined elsewhere [25]-... 

To highlight the continued development and importance of mass spectrometry (MS) methods, we have moved this material to the early part of the text and spht it into two chapters, one on theory and instrumentation (Chapter 3) and the other on detailed structural analysis using characteristic fragmentation patterns of common functional groups (Chapter 4). 

Volume rv is entitled Theory and Instrumentation and is composed of six parts Fundamentals, New Ion Trapping Techniques, Fourier Transform Mass Spectrometry, Quadrupole Rod Sets, 3D-Quadrupole Ion Trap Mass Spectrometry, and Photochemistry of Trapped Ions. 

Practical Aspects of Trapped Ion Mass Spectrometry Theory and Instrumentation, Vol. IV, 2010. 

Goodlett, D.R. Gale, D.C. Guiles, S. Crowther, J.B. Mass spectrometry in pharmaceutical analysis. In Encyclopedia of Analytical Chemistry Applications, Theory and Instrumentation, Meyers, R.A. Ed. John Wiley Sons Chichester, England, 2000 Vol. 8, 7209-7278. 

See also Atomic Absorption, Methods and Instrumentation Atomic Absorption, Theory Atomic Emission, Methods and Instrumentation Biomedical Applications of Atomic Spectroscopy Forensic Science, Applications of Atomic Spectroscopy Hyphenated Techniques, Applications of in Mass Spectrometry Inductively Coupled Plasma Mass Spectrometry, Methods Inorganic Chemistry, Applications of Mass Spectrometry. 

See also Contrast Mechanisms in MRI Diffusion Studied Using NMR Spectroscopy Food and Dairy Products, Applications of Atomic Spectroscopy Food Science, Applications of Mass Spectrometry High Resolution Solid State NMR, Industrial Applications of IR and Raman Spectroscopy Labelling Studies in Biochemistry Using NMR MRI Applications, Biological MRI Instrumentation MRI Theory MRI Using Stray Fields NMR Data Processing NMR Relaxation Rates NMR of Solids. 

Ion trap mass spectrometry is a versatile technique of high sensitivity and high specificity. The relatively low cost of commercial instrumentation has permitted a substantial growth in the practice of mass spectrometry. The theory of ion trap operation differs from those of other mass spectrometers and presents an exciting challenge to the mass spectrometry community. 

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