Testosterone patch

Topical Testosterone patch (Testoderm) 4 mj patch, 6 m patch 4-6 mg/day apply to scrotum... 

Testosterone patch (Testoderm TTS) 4 rng/palch, 6 rng/palch 4-6 mg/day apply to arrn buttock, back... 

Testosterone patch (Androderm) 2.5 rng/palch 2.5-5 mg/day apply to arm, back, abdomen, thigh... 

Testosterone can be replaced orally, parenterally, or transdermally (see Table 83-2). Injectable regimens are preferred because they are effective, are inexpensive, and do not have the bioavailability problems or adverse hepatotoxic effects of oral regimens. Testosterone patches and gel are more expensive than other forms and should be reserved for patients who refuse injections. 

Braunstein GD, Sundwall DA, Katz M, Shifren JL, Buster JE, Simon JA, Bachman G, Aguirre OA, Lucas JD, Rodenberg C, Buch A, Watts NB. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women a randomized, placebo-controlled trial. Arch Intern Med 2005 165 1582-9. 

Weiss EL, Bowers MB Jr, Mazure CM. Testosterone-patch-induced psychotic mania. Am J Psychiatry 1999 156(6) 969. 

Mazer N, Fisher D, Fischer J, et al. Transfer of transdermal apphed testosterone to clothing a comparison of a testosterone patch versus a testosterone gel. J Sex Med 2005 2(2) 227-234. 

Dosage forms with different mechanisms may bypass the organ of absorption, such as the GI tract. These include, for example, the transdermal testosterone patch. Also capable of bypass is the metered dose inhaler for pulmonary delivery of biological products such as a peptide or protein, with a propellant for lung absorption. 

Testosterone replacement regimens can be administered orally, parenterally, and topically (see Table 81-3). Injectable testosterone replacement regimens are preferred for treatment of symptomatic patients with primary or secondary hypogonadism because they are effective, inexpensive, and not associated with the bioavailability problems or hepatotoxic adverse effects of oral androgens. " Although convenient for the patient, testosterone patches and gels are much more expensive than other forms of androgen replacement therefore... 

Topical testosterone replacement regimens can be delivered as once-daily patches or gel. Testosterone patches increase serum testosterone levels into the normal range in 2 to 6 hours. Serum testosterone levels return to baseline 24 hours after patch administration. However, unlike oral or injectable supplements, topical testosterone products, usually applied each morning, produce physiologic patterns of serum testosterone levels throughout the day. The clinical importance of this biochemical effect is unknown. ... 

Topical testosterone patches may cause contact dermatitis, which responds well to topical corticosteroids. 

Anonymous. Testosterone patches for hypogonadism. Med Lett Drugs Ther 1996 38 49-50. 

For the man with symptomatic hypogonadism (decreased libido, energy loss, and erectile dysfunction), a normal prostate examination, and a normal serum prostate-specific antigen, testosterone can be considered as adjunctive therapy. Testosterone patches (2.5-5 mg daily), intramuscular injections (10 to 400 mg every 2 to 4 weeks), 1% topical gel, pellet implants (150 50 mg every 3-6 months), and a buccal formulation are available (see Table 88-6). Testosterone replacement increases bone density in men. The benefits of therapy need to be... 

Mazer, N Bell, D., Wu, J., Fischer, J., Cosgrove, M. and Eilers, B. (2005) Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men. Journal of Sexual Medicine, 2, 213-226. 

Hypogonadism in boys, men replacement therapy Testosterone enanthate or cypionate methyttestosterone fluoxymesterone, testosterone (patch)... 

Androgens such as stanozolol (11), nandrolone (11), methandrostenolone, and the testosterone patch have been shown to increase bone mass by 5 to 10% and may be appropriate for men with a deficiency in testosterone. 

Transdermal patches of testosterone also have problems A fraction of the testosterone is metabolized in the skin and converts to dihydrotestosterone. This metabolic side product can cause swelling of the prostate gland. Testosterone patches are placed on the body where the rate of absorption is highest, but this unfortunately can cause the metabolic product, dihydrotestosterone, to create side effects. Improved patches can be placed in areas where metabolized dihydrotestosterone is minimized. Reduction of transdermal absorption by the changed application area can be overcome by the addition of an absorptive aid. 

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