Testicular germ cells

Matsushime, H Jinno, A., Takagi, N and Shibuya, M. (1990). A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis. Mol. Cell. Biol. 10 2261-2268. 

Voorhoeve PM, le Sage C, Schrier M et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006 124 1169-1181. 

Fung MK, Cheung HW, Ling MT et al. Role of MEK/ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cells. Br J Cancer 2006 95 475 84. 

DIA, DNA strand breaks/cross-links, rat testicular germ cells in vitro + NT 17.3 Bradley Dysart (1985)... 

Bradley. M.O. Dysart. G. (1985) DNA single-strand breaks, double-strand breaks, and crosslinks in rat testicular germ cells measurements of their fonnation and repair by alkaline and neutral filter elution. Cell Biol. Toxicol.. 1. 181-185... 

Rat (Wistar) 30 d 1x/d (GO) 50 M (33% lower testicular weight) 250 M (57% lower testicular weight, testicular germ cell damage) Parmaretal. 1995... 

Lee J, Richburg JH, Shipp EB, et al 1999. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in sertoli cell versus germ cell injury of the testis. Endocrinology 140 852-858. 

Hoei-Hansen CE, Holm M, Rajpert-De Meyts E, Skakkebaek NE (2003) Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer. J Pathol, 200 370-374. 

The second most common tumor in LE is testicular germ cell cancer [43], and these patients usually harbor antibodies to the Ma2 protein. Antibodies to Ma2 antigen alone are usually associated with testicular cancer. Similar to many other onconeural antibodies, Ma2 is associated with clinical multi-focality. Many patients have symptoms of brain stem and hypothalamic dysfunction, and only one-fourth of Ma2 positive patients exhibit classical LE [45]. Patients with antibodies to the major antigen Ma2 and antibodies to Mai or Ma3 have different tumors [43, 46], and are more likely to have additional neurological signs [45],... 

Pont J, Albrecht W. Fertility after chemotherapy for testicular germ cell cancer. Fertil Steril 1997 68(l) l-5. 

Hansen PV, Glavind K, Panduro J, Pedersen M. Paternity in patients with testicular germ cell cancer pretreatment and post-treatment findings. Eur J Cancer 1991 27(ll) 1385-9. 

Vinblastine is used in combination with other cytotoxic agents for the treatment of disseminated Hodgkin s disease stages III and IV, non-Hodgkin s lymphoma, histiocytic lymphoma, and advanced carcinoma of the testis. It has also been used for the treatment of bladder cancer, melanoma, and renal cell cancer. The usual adult dosage is 3-6 mg/m intravenously for the treatment of testicular germ cell tumors and Hodgkin s disease (1,2). 

Bajpai M, Gupta G, Jain SK, et al. Lipid metabolising enzymes in isolated rat testicular germ cells and changes associated with meiosis. Andrologia. 1998 30(6) 311-315. 

Yin Y, Hawkins KL, DeWolf WC, Mor-gentaler A. 1997. Heat stress causes testicular germ cell apoptosis in adult mice. 

Richburg JH, Nanez A, Williams LR, Em-bree ME, Boekelheide K. 2000. Sensitivity of testicular germ cells to toxicant-induced apoptosis in gld mice that express a non-functional form of FasL. Endocrinology 141 787-93... 

Patients with malignant disease show increased LD activity in serum up to 70% of patients with fiver metastases and 20% to 60% of patients with other nonhepatic metastases have elevated total LD activity. Notably elevated LD-1 is observed in germ cell tumors (61% of cases), such as teratoma, seminoma of the testis, and dysgerminoma of the ovary. Patients with seminoma have a raised LD-1 m 63% of cases compared with 60% in nonseminoma cases. The percent of patients with increased LD-1 depended on the stage of the disease. LD-1 appeared to be a useful predictor of outcome in patients with testicular germ cell tumors. 

Ojha, P., Dhar, J. D., Dwivedi, A. K., Singh, R. L., and Gupta, G. (2008). Rat testicular germ cell type(s) targeted by anti-spermatogenic agents in vivo and their recovery on withdrawal of treatment—A flow cytometric study. Anim. Reprod. Sci. 103,135-148. 

Mbikay, M., Tadros, H., Ishida, N., Lemer, C.P., De Lamirande, E., Chen, A., El-Alfy, M., Clermont, Y., Seidah, N.G., Chretien, M., Gagnon, C., and Simpson, E.M. (1997). Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proc. Natl. Acad. Sci. USA 94 6842-6846. McDowell, R.S., Dennis, M., Louie, A., Shuster, M., Mulkerrin, M.G., and Lazarus, R.A. (1992). Mambin, a potent glycoprotein Ilb-IIIa antagonist and platelet aggregation inhibitor. Biochemistry 37 4766-4772. 

Marks A, Sutherland DR, Bailey D, et al. Gharacterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumors. Br J Cancer. 1999 80 569-578. 

Jacobsen GK, Norgaard-Pedersen B. Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study. Acta Pathol Microbiol Immunol Scand [A]. 1984 92 323-329. 

Burke AP, Mostofi EK. Placental alkaline phosphatase immunohistochemistry of intratubular malignant germ cells and associated testicular germ cell tumors. Hum Pathol. 1988 19 663-670. 

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