Technetium sulfur colloid

Kharasch VS, Sweeny TD, Fredberg J, Lehr J, Damokosh Al, Avery ME, et al. Pulmonary surfactant as a vehicle for intratracheal delivery of technetium sulfur colloid and pentamidine in hamster lungs. Am Rev Respir Dis 1991 144 909-913. 

An exception is technetium sulfide (TcjSy), known as " Tc-sulfur colloid (Stern et al. 1966). Scavenging molecules like phosphinimine (R3P = N-SiMe3) have been reported to incorporate TcO, producing organic molecules containing Tc(VII) (Katti et al. 1993 Singh et al. 1995). 

Technetium[ Tc] sestamibi injection Technetium[ Tc] succimer injection Technetium[ Tc] sulfur colloid Injection... 

Technetium Tc 99m succimer injection Technetium Tc 99m sulfur colloid injection... 

Klingensmith WC III, Tsan ME, Wagner HN Jr (1976) Factors affecting the uptake of ""Tc-sulfur colloid by the lung and kidney. J Nucl Med 17 681 Lin MS, Winchell HS (1972) A kit method for the preparation of a technetium-tin(II) colloid and a study of its properties. J Nucl Med 13 58-65 Marciniak M (1981) Bivalent tin metabolism and toxicity after intravenous injection in rats. Acta Physiol Pol 32 2... 

Chemical name Technetium " Tc colloidal rhenium sulfide injection Ph. Eur.) Technetium Tc 99m sulfur colloid injection USP) " Tc-(Re)-sulfide colloid " Tc-sulfur colloid Listed trade names HepatoCis (TCK-1) (1) Sulfotec Sorin (2) ... 

Council of Europe (2005 a) Technetium ""Tc colloidal rhenium sulphide injection. Emopean pharmacopeia 5.0, monograph, no 126. Council of Europe, Maisonneuve, Sainte-Ruffine Council of Europe (2005 b) Technetimn " Tc sulfur colloid injection. Emopean pharmacopeia 5.0, monograph, no 131. Coimcil of Emope, Maisonneuve, Sainte-Ruffine Haney TA, Ascanio I, Gighotti JA, Gusmano EA, Bruno GA (1971) Physical and biological properties of a " Tc-sulfur colloid preparation containing disodium edetate. J Nucl Med 12 64-68... 

United States Pharmacopeial Convention (2005) United States Pharmacopeia (USP) 28 official monographs Technetium Tc 99m sulfur colloid injection. United States Pharmacopeial Convention, Rockville, Md, p 1865... 

TECANE (76-03-9) see trichloroacetic acid. TECHNETIUM TC 99M SULFUR COLLOID (7704-34-9) see sulfur. TECQUINOL (123-31-9) see hydroquinone. 

Doss LL, Padilla RS and Hiadik WB (1986) Technetium antimony sulfur colloid scintiscan in selective lymph node dissection for malignant melanoma. 

Figure 3. Tomographic section of Go platelets localizing in an experimentally induced pulmonary embolus. The left panel shows the prelabeled emboli visualized on an Anger camera the emboli have been prelabeled with technetium-99m—sulfur colloid. The middle panel shows the transmission scan used to correct the image for atteruMtion in various parts of the lung. The right panel shows the localization of the Ga platelets in the two emboli shown in the left panel.

Adenoma cells are arranged in cords and separated by sinusoids (Ishak 1994). The tumor lacks portal tracts or bile ducts, a key histological feature that helps distinguish hepatocellular adenoma from focal nodular hyperplasia (Boulahdour et al. 1993). Kupffer s cells are found in adenomas but probably they are often decreased in number or less functional than normal liver tissue, as reflected by absent or diminished uptake of technetium (Tc)-99m sulfur colloid (Fig. 10.1) (Rubin and Lichtenstein 1993). Because this neoplasm has no portal tracts, the tumor perfusion occurs solely by peripheral arterial feeders therefore the hypervascular nature of adenoma, related to sinusoids and feeding arteries, associated with poor connective tissue support, can lead frequently to hemorrhage. Because a tumor capsule is usually absent or incomplete, hemorrhage may spread into the liver or abdominal cavity (Molina and ScHiFF 1999). 

Fig. 10.1a,b. Non-complicated hepatocellular adenoma, a On CT scan during the arterial phase after contrast medium administration the neoplasm becomes homogeneously hyperdense (asterisk) compared to the surrounding liver parenchyma, b Nuclear medicine shows absent uptake of technetium (Tc)-99m sulfur colloid, and the lesion is seen as cold defect ... 

Tc-(Re)-sulfide colloid is formed at acidic pH in the boiling water bath. The reaction is based on the formation of colloidal sulfur and technetium heptasulfide (TC2S7) at acidic pH. Rhenium is used as a carrier (Larson and Nelp 1966 Patton et al. 1966). Ten milligrams of sodium thiosulfate pentahydrate generate 2 mg of colloidal sulfur (Stern et al. 1966). The added Tc eluate should not be less than 5 ml, the Tc activity not less than 370 MBq (10 mCi). 

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