Taste blindness

Many bixxer compounds contain both hydrophobic and hydrophilic sites which can alter cell membranes through penetration. There is a correlation between bitter intensity and hydrophobicity-solubility indexes such as fee octanol/water partition coefficient, lo (7). Penetration may directly affect cAMP phosphodiesterase as part of fee transduction process (see below). A bitter receptor protein may be involved wife certain bitters, such as specific structural requirements wife fee bitter tasting dipeptides and denatonium salts (27). The latter is used in some consumer products to avoid accidental ingestion. A receptor mechanism is also supported by fee existence of a genetic "taste blindness" for some bitter materials (see below). 

Up to this point we have assumed that the product will be tasted by tasters who know which product is which. Another approach is to taste blind where the taster does not know which piece comes from which batch. The aim of these tests is to find if there is a significant difference between the samples. 

Aihara Y, Yasuoka A, Iwamoto S, Yoshida Y, Misaka T, Abe K (2008) Construction of a taste-blind medaka fish and quantitative assay of its preference-aversion behavior. Genes Brain Behav (in press)... 

TAP 29 484 TaqMan 84 TAR RNA decoys 231 Tarceva 143, 1122 Tasonermin 463, 479 Taste blindness 74 TATA box 764 Taurodeoxycholate 1376 Taxanes 140, 1252 Taxol 314, 835 Taxotere 101 Taxus cuspidata 950 TAXUS trial 315 Tazl 43... 

The amino acids L-leucine, T-phenylalanine, L-tyrosine, and L-tryptophan all taste bitter, whereas their D-enantiomers taste sweet (5) (see Amino ACIDS). D-Penicillamine [52-67-5] a chelating agent used to remove heavy metals from the body, is a relatively nontoxic dmg effective in the treatment of rheumatoid arthritis, but T.-penicillamine [1113-41 -3] produces optic atrophy and subsequent blindness (6). T.-Penicillamine is roughly eight times more mutagenic than its enantiomer. Such enantioselective mutagenicity is likely due to differences in renal metaboHsm (7). (R)-ThaHdomide (3) is a sedative—hypnotic (3)-thaHdomide (4) is a teratogen (8). 

The aim of our project was to study phloem as a source of fiber and polyphenols, and to develop a method to improve its taste without losing the potentially bioactive polyphenols. In addition, we wanted to investigate the bioavailability, cholesterolemic and antioxidative effects and safety of phloem and its phytonutrients in humans in a randomised double-blind trial. 

There are at least 26 different flavorings used in pediatric antimicrobial preparations [70]. Cherry is the most commonly used flavoring, although a blind taste comparison found that other flavorings, such as orange, strawberry, and bubble gum, are well accepted in pediatric antimicrobial suspensions [98],... 

M. Ruff, D. Schotik, J. Bass, and J. Vincent, Antimicrobial drug suspensions a blind comparison of taste of fourteen common pediatric drugs, Pediatr. Infect. Dis. J., 10, 30 (1991). 

A turning point came when I finally detected that I was reacting to ordinary things in our house. Every time I walked near the window blinds I felt like they were knocking me over and I could taste chemicals in my mouth. I didn t know if my husband would believe me or not, but in my desperation I ripped down all the blinds in the house. When he came home all the blinds were outside in the garbage. After that I noticed a chemical taste in my mouth every time I opened a kitchen cupboard. We figured out that it was from the formaldehyde in the particleboard, so Ron replaced all the particleboard in the... 

Spiny mice, Acomys cahirinus, use all senses interchangeably in locating prey (Langley, 1988). These are cases of adaptive redundancy at the level of the sensory modalities. As is well known, deaf-blind humans use smell and taste more. 

Deficiency symptoms Bitot s spots, xerosis, night blindness, keratomalacia, diarrhoea, follicular hyperkeratosis, papular eruptions, drying of epidermis, urinary calculi, degeneration of testis, impaired spermatogenesis, sterility, abortion, impairment of smell and taste. 

The most frequently used tests in quality control in the flavour industry are paired-sample comparison tests, and triangle tests, which are often combined with the description of deviation from a reference item. For the selection and training of panellists, further test methods are used, for example ranking tests for colour, taste and odour, threshold detections (taste, off-flavour), colour blindness tests and odour identification tests [6]. 

Religious or spiritual experience, like any other, is intensely personal and cannot be conveyed in words to one who has not had something similar. We cannot convey even the taste of a strange fruit to one who has not tasted it. The closest we can come to it is to say that it is "something like" the taste of another which we have both experienced. Again, how could we describe the color red, or any color, or even the sense of vision, to one who was born blind ... 

Indeed, some wine makers and experimenters have introduced changes to the usual CM scheme to enhance its aging potential. For example, in a blind tasting (Flanzy, 1998), wine from Chateauneuf-du-Pape were still considered in excellent condition after 20 years. 

Many poisonings by methanol and ethylene glycol occur each year. Alcoholics occasionally drink ethanol that has been denatured by the addition of methanol. Methanol is oxidized to formic acid, which may cause blindness and death. Dogs are often poisoned by sweet-tasting ethylene glycol when antifreeze is left in an open container. Once the glycol is metabolized to oxalic acid, the dog s kidneys fail, causing death. 

Methanol (methyl alcohol). The commercial product is a clear, colourless liquid with a characteristic odour. It boils at 64 7°C and has a density of 0 79 gem"3. It is POISONOUS (causing blindness and ultimately death) and should therefore never be tasted. 

Zolpidem 10 mg/day and zopiclone 7.5 mg/day, given at night, have been compared in a 14-day, double-blind study in 479 chronic primary insomniacs (17). With zolpidem 68% of the patients were rated at least moderately improved, versus 62% with zopiclone. However, with zolpidem sleep-onset latency improved in significantly more patients (86 versus 78%). In addition, significantly fewer patients who took zolpidem had drug-related adverse events (31 versus 45%) bitter taste accounted for 5.8% of such complaints with zolpidem compared with 40% with zopiclone. In conclusion, zolpidem was at least as effective as zopiclone but showed significantly less rebound on withdrawal overall it was better tolerated. 

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