Tartrazine FD C Yellow

Dyes. Dose does not appear to be a factor in patient reaction to dyes. The mandatory labeling of the azo dye tartrazine (FD C yellow No. 5) in OTC and prescription medications [58] has focused the attention of pharmaceutical manufacturers and the consumer on the potential danger of dyes in susceptible individuals. 

Tartrazine sensitivity Some of these products contain tartrazine (FD C yellow 5),... 

Tartrazine, FD C yellow 5 102 19140 A Trisodium-5-hydroxy-1 -(4-sulfophenyl)-4-(4-sulfophenylazo)-pyrazole-3-carboxylate C 6H9N4Na309S2 534.37 426- 435... 

Tofranil-PM(r) (imipramine pamoate) 100-and 125-mg capsules contain the dye tartrazine (FD C yellow No. 5), which may cause allergic reactions in some patients this reaction is more likely in patients with sensitivity to aspirin... 

TARTRAZINE TARTRAZINE A EXPO T TARTRAZINE B TARTRAZINE B.P.C. TARTRAZINE EXTRA PURE A TARTRAZINE FD C YELLOW 5 TARTRAZINE FQ TARTRAZINE G TARTRAZINE LAKE TARTRAZINE LAKE YELLOW N TARTRAZINE M TARTRAZINE MCGL TARTRAZINE N TARTRAZINE NS TARTRAZINE O TARTRAZINE T... 

Lockery SD, Sr. Hypersensitivity to tartrazine (FD C Yellow No. 5) and other dyes and additives present in foods and pharmaceutical products. Ann Allergy mi 38 206-10. 

The azo dye tartrazine (FD C Yellow No. 5) is associated with anaphylactoid reactions, acute bronchospasm, urticaria, rhinitis, and contact dermatitis. Although the immunologic mechanisms are unclear, approximately 10% of aspirin-sensitive asthmatics are also intolerant to tartrazine, suggesting a role for tartrazine as a cyclooxygenase inhibitor. As little as 0.85 meg or as much as 25 mg tartrazine has provoked positive responses. ... 

FD C Yellow No. 5. See Tartrazine FD C Yellow No. 5 aluminum lake CAS 12225-21-7 12227-69-9 53026-63-4 EINECS/ELINCS 235-428-9 Synonyms Acid yellow 23 aluminum lake (INCI) Cl 19140 1... 

Ershoff, B.H. (1977). Effects of diet on growth and survival of rats fed toxic levels of tartrazine (FD C Yellow No. 6). 

The color additive most often associated with adverse effects is FD C Yellow No. 5, or tartrazine (Jones, 1992 Fuglsang et al., 1993). From 1980... 

MJ Prival, MD Peiperl, SJ Bell. Determination of combined benzidine in FD C yellow no. 5 (tartrazine). Food Chem Toxicol 33(10) 751-758, 1995. 

In 1985 the FDA published specifications for free amines in FD C Yellow No. 6 (or Sunset Yellow, l-(4 -sulfo-l -phenylazo-)2-naphthol-6-sulfonic acid disodium salt), and FD C Yellow No. 5 (or tartrazine, 4,5-dihydro5-oxo-l-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-l//-pyra-zole-3-carboxylic acid trisodium salt) and expressed concern about amines in other colors (208). 

Both the European Union and the FDA have pubhshed lists that are subject to regular review. The greatest concern has been expressed over the use of azodye colours as certain individuals can demonstrate an allergic reaction to some of these. Allergic reactions have been reported most frequently for sunset yellow (E110, FD C yellow no. 6) and tartrazine (E102, FD C yellow no. 5). 

Color modification Synthetic dyes Tartrazine (FD C yellow5) Sunset Yellow... 

To be used or sold for use to color food that is marketed in the United States, this color additive must be from a batch that has been certified by the U.S. Food and Drug Administration (FDA). If it is not from an FDA-certified batch, it is not a permitted color additive for food use in the United States, even if it is compositionally equivalent. The name FD C Yellow No. 5 can be applied only to FDA-certified batches of this color additive. Tartrazine is a common name given to the uncertified colorant. See the monograph entitled FD C Yellow No. 5 for directions for producing an FDA-certified batch. 

Although this theory was popularized in the 1970s, well-controlled studies conducted since then have produced no evidence that food and drug color additives such as azo dyes (FD C yellow 5, FD C yellow 6, etc.) cause hyperactivity or learning disabilities in children. A Consensus Development Panel of the National Institutes of Health concluded in 1982 that there was no scientific evidence to support the claim that colorings or other food additives cause hyperactivity. The panel said that elimination diets should not be used universally to treat childhood hyperactivity, because there is no scientific evidence to predict which children may benefit. The FDA s Advisory Committee on Hypersensitivity to Food Constituents concluded in 1986 that FD C yellow 5 (tartrazine) might cause hives in fewer than 1 out of 10,000 people. The Committee found that there was no evidence the color additive in foods provokes asthma attacks or... 

This product contains FD C yellow 5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible persons. 

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