Target, targets validation

However, the target validation step is unique to target-based drug discovery. 

Inhibitors of the Angiopoietin/Tie-2 and Ephrin/Eph systems are in preclinical development which parallels the biological target validation of these molecules. As vascular assembly, maturation, and homeostasis regulating molecules, therapeutic interference with these molecular systems may hold promise for a number of vascular indications. 

Target validation, to determine that a gene product is causative of disease symptoms or that activation of the target protein ameliorates disease symptoms. Agonist/activator or an inhibitor which may be therapeutic could be identified using microarrays... 

Marton MJ et al. Drug target validation and identification of secondary drug tar-... 

INTERCONNECTING DISEASE, TARGET VALIDATION MODELS, AND PHARMACOLOGICAL RESPONSE... 

Strachan, R.T., Ferrara, G. and Roth, B.L. (2006) Screening the receptorome an efficient approach for drug discovery and target validation. Drug Discovery Today, 11, 708-716. 

Drug-discovery process is a highly complex, multidisciplinary and time-consuming procedure, which typically starts from the identification of appropriate drug targets (biomolecules, enzymes, ion channels, receptors) to target validation, where it was established whether the target was of relevance for the disease under study. 

Xin, H., Bernal, A., Amato, F.A., Pinhasov, A., Kauffman, J., Brenneman, D.E., Derian, C.K., ndrade-Gordon, P., Plata-Salaman, C.R., and Ilyin, S.E., High-throughput siRNA-based functional target validation, /. Biomol. Screen., 9, 286, 2004. 

Sundberg, S.A., Chow, A., Nikiforov, T., and Wada, H.G., Microchip-based systems for target validation and HTS, Drug Discov. Today, 5, 92, 2000. 

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