Target Identification and Validation

The process of target identification analyzes a complex disease process by dissecting it into its fundamental components. This makes it possible to identify the one that is most integral to the manifestation of the disease. Target identification aims to understand the biological processes related to a disease, and to identify its mechanism and the structure of individual elements of the disease. Commonly these individual elements are receptors, enzymes, etc., which become the target of new drugs. 

ON A alkylating agents, intercalating agents, wrong substrates (Trofan horses, e.g, S-fluorouracil) 

---

Darnell, J. C., Mostovetsky, O., and Darnell, R. B. (2005). FMRP RNA targets Identification and validation. Genes Brain Behav. 4, 341-349. 

Jurgen Moll and Riccardo Colombo (eds.), Target Identification and Validation in Drug Discovery Methods and Protocols, Methods in Molecular Biology, vol. 986, DO110.1007/978-1 -62703-311 -4 1, Springer Science+Business Media New York 2013... 

Jurgen Moll and Riccardo Colombo (eds.), Target Identification and Validation in Drug Discovery ... 

Genetically Engineered Animal Models for In Vivo Target Identification and Validation in Oncology... 

Mazzoletti M, Texido G. (2013) In vivo target validation by inducible RNAi in human xenograft mouse models, methods in molecular biology. Target identification and validation in drug discovery. Eds. Jurgen Moll and Riccardo Colombo. 

---