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Disease, Target Validation Models, and Pharmacological Response

INTERCONNECTING DISEASE, TARGET VALIDATION MODELS, AND PHARMACOLOGICAL RESPONSE [Pg.419]

Neurodegeneration Alzheimer s Cortical neurons B-amyloid Markers of B-amyloid induced neurotoxicity [271 [Pg.420]

Neurodegeneration, microglial activation BV-2 microglial cells Lipopolysaccharide, HIV protein TAT, dopamine quinone Gene ontology analysis of common pathway response [28] [Pg.420]

Peripheral nerve regeneration Nerve lesion nerve development Time course Comparison suggests regeneration partially recapitulates development [29] [Pg.420]

Granulocyte differentiation acute promyelocytic leukemia PBMCs (in vivo) Cultured bone marrow mononuclear cells (in vitro) All-trans retinoic acid (ATRA) Promoter analysis of ATRA response genes suggest molecular mechanism underlying ATRA-induced granulocytic differentiation [30] [Pg.420]




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Disease models

Disease targets

Modeling validation

Models validity

Pharmacological response

Response model

Response, target

Target validation

Target, targets validation

Validated target

Validation Responsibilities

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