Disease, Target Validation Models, and Pharmacological Response

INTERCONNECTING DISEASE, TARGET VALIDATION MODELS, AND PHARMACOLOGICAL RESPONSE 

Neurodegeneration Alzheimer s Cortical neurons B-amyloid Markers of B-amyloid induced neurotoxicity [271 

Neurodegeneration, microglial activation BV-2 microglial cells Lipopolysaccharide, HIV protein TAT, dopamine quinone Gene ontology analysis of common pathway response [28] 

Peripheral nerve regeneration Nerve lesion nerve development Time course Comparison suggests regeneration partially recapitulates development [29] 

Granulocyte differentiation acute promyelocytic leukemia PBMCs (in vivo) Cultured bone marrow mononuclear cells (in vitro) All-trans retinoic acid (ATRA) Promoter analysis of ATRA response genes suggest molecular mechanism underlying ATRA-induced granulocytic differentiation [30] 

---