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Chemical validation, enzyme targets

One of the most compelling targets in the polyamine biosynthesis pathway has been S-adenosylmethionine decarboxylase (SAM-DC). This target was chemically validated with the discovery of trypanocidal activity of MDL-73811 nearly two decades ago. Work to understand the unique kinetics for inhibition of this enzyme in T. brucei has shown that a catalytically... [Pg.281]

Integrase (IN) is a crucial enzyme in the life cycle of human immunodeficiency virus type 1 (HIV-1) that has recently been validated as an antiviral target by the FDA approval of the IN inhibitor MK-0518 (raltegravir) for the treatment of HIV/AIDS. Several chemical families of highly potent IN inhibitors have been reported, which are believed to function by chelating catalytically essential divalent metal... [Pg.179]

See other pages where Chemical validation, enzyme targets is mentioned: [Pg.411]    [Pg.49]    [Pg.617]    [Pg.560]    [Pg.163]    [Pg.163]    [Pg.137]    [Pg.287]    [Pg.7]    [Pg.407]    [Pg.408]    [Pg.413]    [Pg.320]    [Pg.321]    [Pg.7]    [Pg.15]    [Pg.427]    [Pg.471]    [Pg.229]    [Pg.327]    [Pg.94]    [Pg.73]    [Pg.1387]    [Pg.444]    [Pg.1611]    [Pg.285]    [Pg.5]    [Pg.109]    [Pg.235]    [Pg.119]    [Pg.299]    [Pg.202]    [Pg.372]    [Pg.205]    [Pg.535]    [Pg.254]    [Pg.4]    [Pg.409]    [Pg.410]    [Pg.1118]    [Pg.214]   
See also in sourсe #XX -- [ Pg.411 , Pg.412 ]



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Chemical target validation

Chemical validation

Enzyme validation

Enzymes targetting

Target chemicals

Target validation

Target, targets validation

Validated target

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