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Human genome target validation

The protein kinases in a proteome of an organism. See Manning, G., Whyle, D.B., Martinez, R., Hunter, T., and Sudarsanam, S., The protein kinase complanent of the human genome. Science 298,596-601,2(XX) ter Haar, E., Walters, W.P., Pazhanisamy, S. et al.. Kinase chemogenomics targeting the human kinome for target validation and drag discovery. Mini Rev. Med. Chem. 4, 235-253,2004. [Pg.142]

The identification of novel receptor targets from the human genome and their subsequent use in the drug discovery process requires that the target be validated. Validation requires that the ligand and function of the receptor be known, and this topic has been addressed in relation to orphan receptors above. [Pg.336]

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Genomic targets

Human genome

Human validation

Target validation

Target, targets validation

Validated target

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