Target identification, drug discovery

Stephen L. Madden, Clarence J. Wang and Greg Landes, Serial analysis of gene expression from gene discovery to target identification. Drug Discovery Today, 5 (2000), 415-425. 

Identification and functional characterization of genes Genomics is the identification of previously unknown human DNA sequences encoding natural human proteins with previously unknown medical use that can be used as targets in Drug Discovery to discover novel therapeutic agents or administered for therapeutic benefit. 

Burgstaller, P., Girod, A. and Blind, M. (2002) Aptamers as tools for target prioritization and lead identification, Drug Discovery Today 7, 1221-1228. 

The objectives of the Metals in Medicine Program Announcement (PA-01-071 now reissued as PA-05-001) are i) identification of new targets for drug discovery ii) development of new in vitro and in vivo diagnostics iii) elucidation of new basic concepts that will enable future therapeutics development dnd iv) stimulation of collaborations between inorganic chemists and medical scientists to ultimately increase flie inqiact of bioinorganic chemistry research on health. 

Akritopoulou-Zanze I (2006) The identification of new protein kinase inhibitors as targets in modern drug discovery. ID rugs 9 481-487... 

In the realm of drug discovery, the detection and characterization of target-ligand interactions is a critical process for lead identification, validation, and optimization. 

---