Target prioritization

Burgstaller, P., Girod, A. and Blind, M. (2002) Aptamers as tools for target prioritization and lead identification, Drug Discovery Today 7, 1221-1228. 

II. Product Summary Jubilant Biosys has created some content products in the bioinformatics and chemoinformatics area. These products leverage Jubilant s curation services to incorporate extensive curated databases with structured query modules and front-ends for data retrieval. The content is for the drug discovery process, specifically in the areas of target prioritization and lead identification. The databases are available in Oracle, SD format, and ISIS/Base DB formats and can be exported. The database can be queried across text, structure, substructure and sequences with built-in query modules. Some of the key parameters on which information is curated are ... 

Hu, W. et al. 2007. Essential gene identification and drug target prioritization in Aspergillus fumigatus. PLoS Pathog. 3, e24. 

There are several ways in which structural genomics has promise as a tool for genome annotation and target prioritization. For genes of unknown function, structure can often provide clues to biochemical function. Sequence homology has become a routine method for functional assignment, but even the most... 

Judson R, Houck K, Kavlock RJ, Knudsen T, Martin T, Mortensen HM, Reif D, Rotroff D, Shaha I, Richard AM, Dix DJ (2010) In vitro screening of environmental chemicals for targeted testing prioritization the ToxCast project. Environ Health Perspect 118 485-492... 

Combating Terrorism Threat and Risk Assessments Can Help Prioritize and Target Program Investments. Washington, D.C. U.S. Government Accounting Office (NSIAD-98-74, April 9) 1998.. 

In this chapter, the full BioPrint approach is described, as available from Cerep in terms of both the data set and the ability to have new compounds profiled and the results provided in the context of the BioPrint data set, including the known in vivo side effects of near neighbors in this biological space (see Section 2.5). The results for the differentiation of hit/lead compounds (see Section 2.3.2.1) sometimes use a subset of the 70-100 pharmacological assays that provide the maximum signal. Usually a decision on future work prioritization could be clearly made from the data from these subsets, saving time and money. For key reference/tool compounds, a full profile was used and is recommended to be used, as unexpected off-target activities may be found that cannot usually be predicted. 

For existing facilities, security upgrades should be based on the results generated from the vulnerability assessment, which characterizes and prioritizes those assets that may be targeted. The vulnerabilities identified must be protected. 

For the prioritization of virtual compound libraries based on biostructural information, usually a fixed target structure is assumed and the energetically minimized conformers... 

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