Tabun toxicology

Bucci, T.J., R.M. Parker, J.A. Crowell, J.D. Thurman, and P.A. Gosnell. 1992. Toxicity Studies on Agent GA (Phase II) 90 Day Subchronic Study of GA (Tabun) in CD Rats. Final Report. DTIC AD-A258042. Prepared by Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, Ark., for the U.S. Army Biomedical Research and Development Laboratory, Fort Detrick, Frederick, Md. 

Bucci, T.J., J.D. Fikes, R.M. Parker, K.H. Denny and J.C. Dacre. 1993. Developmental Toxicity Study (Segment II Teratology) of Tabun in CD Rats and in New Zealand White Rabbits. National Center for Toxicological Research, Final Report Nos. E515 and E516. Prepared for the U.S. Army Medical Research and Development Command, Fort Detrick, MD. 

Henderson, J.D., R.J. Higgins, J.C. Dacre, et al. 1992. Neurotoxicity of acute and repeated treatments of tabun, paraoxon, diisopropyl fluorophosphate and isofenphos to the hen. Toxicology 72 117-129. 

Gupta, R.C., Patterson, G.T., Dettbam, W-D. (1988). Acute tabun toxicity biochemical and histochemical consequences in brain and skeletal muscle of rat. Toxicology 46 329-42. 

ToxNet, Toxicology data network. Hazardous Substances Data Bank (HSDB), United States National Library of Medi-cine data for tabun http //toxnet.nlm.nih.gov/cgi-bin/sis/ search/f ./temp/ 87NcK0 l data for sarin http //toxnet.nhn. nih.gov/cgi-bin/sis/search/f ./temp/ jfAOcY l data for soman http //toxnet.nlm.nih.gOv/cgi-bin/sis/search/f7./temp/... 

Lundy, P.M., Hansen, A.S., Hand, B.T., Boulet, C.A. (1992). Comparison of several oximes against poisoning by soman, tabun and GF. Toxicology 72 99-105. 

Calic, M., Lucic-Vrdoljak, A., Radic, B., Jelic, D., Jun, D., Kuca, K., Kovarik, Z. (2006). In vitro and in vivo evaluation of pyridinium oximes mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity. Toxicology 219 85-96. 

Kassa, J., Karasova, J., Musilek, K., Kuca, K. (2008). An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology 243 311-16. 

Odzak, R., Calic, M., Hrenar, T., Primozic, I., Kovarik, Z. (2007). Evaluation of monoquatemary pyridinium oximes potency to reactivate tabun-inhibited human acetylcholinesterase. Toxicology 233 85-96. 

Van Den Berg, G.R., Beck, H.C., and Benschop, H.P. 1984. Stereochemical analysis of the nerve agents soman, sarin, tabun, and VX by proton NMR-spectroscopy with optically active shift reagents. Environmental Contamination Toxicology, 33 505-514. 

Kassa, J., and Vachek, J., A comparison of the efficacy of pyridostigmine alone and in the combination of pyridostigmine with anticholinergic drugs as pharmacological pretreatment of tabun-poisoned rats and mice, Toxicology, 177, 179-185,2002. 

Gupta RC, Patterson GT and Dettbarn W-D (1987a). Acute tabun toxicity biochemical and histochem-ical consequences in brain and skeletal muscles of rats. Toxicology, 46, 329-341. 

Bucci, T. J., Parker, R. M., Crowell, J. A., Thurman. J. D.. and Gosnell, P, A. (1992a). Toxicity studies on agents GA (phase II) 90-day subchronic study of CA (tabun) in CD rats, Final report (DTIC AD-A258042). Prepared by the National Center for Toxicological Research, Jefferson, AR, for the U.S. Department of the Army, Biomedical Research and Development Laboratory, Ft, Detrick, MD. 

K39. Krejcova, G., and Kassa, J., Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats. Toxicology 185, 129-139 (2003). 

Bucci TJ, Parker RM, CroweB JA, Thurman JD, Gosnell PA. Toxicity Studies on Agent GA (Phase II) 90 Day Subchronic Study of GA (Tabun) in CD Rats. Jefferson, Ark National Center for Toxicological Research 1992. 

Wilson BW, Kawakami TG, Cone N, Henderson JD, Rosenblatt LS, Goldman M (1994) Genotoxicity of the phosphoramidate agent tabun (GA). Toxicology 86 1-12. 

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