Tabun Poisoning

Arterial press - increased Bowel movements, control - decrease/loss [ 1 ] Bowel movements - diarrhea Breathing - cessation [1] 

vision - blurred Eyes, vision - dim Eyes - pain [2] 

Mentation, judgement - impaired [5] Mentation, memory - impaired (amnesia) [5] Mentation - confusion [5] 

Muscles, local - movement, fine (fasciculations) Muscles - paralysis [3] 

drainage - increased (rhinorrhea, coryza) Nose - congestion Seizures [1] 

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PAM chloride, HI-6 and HGG 12 in soman and tabun poisoning. Fundam. Appl. 

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Worek, F., Kirchner, T., Szinicz, L. (1994b). Treatment of tabun poisoned guinea-pigs with atropine, HL6-7 or HI-6 effect on respiratory and circulatory function. Arch. Toxicol. 68 231-9. 

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Kassa, J., Karasova, J., Musilek, K., Kuca, K. (2008). An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology 243 311-16. 

Kassa, J., and Vachek, J., A comparison of the efficacy of pyridostigmine alone and in the combination of pyridostigmine with anticholinergic drugs as pharmacological pretreatment of tabun-poisoned rats and mice, Toxicology, 177, 179-185,2002. 

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The notable therapeutic efficacy of HI 6 in soman- and tabun-poisoned non-human primates in the absence of significant AChE reactivation (Hamilton and Lundy, 1989) was attributed in... 

Worek, R, Kleine, A., and Szinicz, L., Effect of pyridostigmine pretreatment on cardiorespiratory function in tabun poisoning, Fhunan Exper. Toxicol., 14, 634, 1995. 

Kassa, J. 2004. Effect of acetylcholine-sterase reactivator dosage on its effectiveness in the treatment of tabun poisoning in mice [Article in Czech]. Ceska. Slav. Farm. 58(1) 31-34. 

K39. Krejcova, G., and Kassa, J., Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats. Toxicology 185, 129-139 (2003). 

Sevelova, L., and Vachek, J., Effect of methoxime combined with anticholinergic, anticonvulsant, or anti-HCN drugs in tabun-poisoned mice. Acta med. (Hradec Karalove) 46, 109-112 (2003). 

The oximes differ in their required doses, their toxicity, and their effectiveness (for example, TMB4 is more effective against tabun poisoning than is 2-PAM Cl). After thorough study of many of these... 

Kassa, J., Karasova, J.Z., Pavlikova, R., et al., 2010. The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice. J. Appl. Toxicol. 30,120-124. 

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