Wet granulation tableting

Khattab, L, Menon, A., and Sakr, A., Effect of mode of incorporation of disintegrants on the characteristics of fluid-bed wet-granulated tablets, J. Pharm. Pharmacol., 45 687-691 (1993). 

In this example, a high dose ( 75% drug loading) wet granulated tablet product was transferred between development sites. The following issues were noted after transfer of the product ... 

Scale-Up of a Sustained Release, Wet Granulation Tableting Process... 

A simple schematic of a wet granulation tableting process can be viewed in Figure 3.3 [11]. 

Gordon MS, Rudraraju VS, Dani K, Chowhan ZT. 1993. Effect of the mode of super dis-integrant incorporation on dissolution in wet granulated tablets. J. Pharm. Sci. 82(2) 220- 226. 

Gordon MS. Rudruraju VS, Rhic JK, ct al. The effect of aging on the dissolution of wet granulated tablets containing super disintegrants. Int J Pharm 1993 97 119-31. 

Figure 10.20 Peak intensity map demonstrating a lack of homogeneity at the outer coat that affected the inner core structure in an HPMC-coated wet granulated tablet.

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