Segregation tablets manufacturing process

Process ability Surface area, surface free energy, crystal defects, and deformation potential affect compressibility and machineability on high-speed tableting machines with reduced compression dwell times Particle size distribution and shape affect flow properties, efficiency of dry mixing process, and segregation potential Compressibility, flow ability, and dilution potential affect the choice of direct compression as a manufacturing process... 

The first demonstration of solid state fluorescence of API dates back to 1961, while its in-line use for final drug product manufacturing was not demonstrated until recently." While in its infancy as a process analytical technology for real-time monitoring and product parametric real-time release, the applications identified and in some instances demonstrated include (i) blend endpoint API content nniformity detection " (ii) segregation monitoring or API content at various process critical control points and (iii) at-line tablet content uniformity determination. The fundamentals of solid-state luminescence spectroscopy for pharmaceutical solids has been covered by Brittain."... 

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