Tablet storage

Calcium Hypochlorite. This chemical, marketed since 1928, is one of the most widely used swimming-pool water sanitizers. Calcium hypochlorite, a crystalline sofld, is a convenient source of available chlorine and is sold in granular or tablet form for use in home, semiprivate, and commercial pools. When dissolved in water, Ca(OCl)2 forms hypochlorous acid and hypochlorite ion similar to NaOCl. It contains small amounts of stabilizing Ca(OH)2, which has a very small effect on pool pH (7). Calcium hypochlorite has superior storage stabiUty and much higher available CI2 concentration than Hquid bleach, which reduces storage requirements and purchasing frequency. 

Properties of lakes that enhance their usefiilness iaclude their opacity, their abiUty to be iacorporated iato products ia the dry state, their relative iasolubihty, and their superior stabiUty toward heat and light. Such properties have made possible the more effective and more efficient preparation of candy and tablet coatings, and often eliminate the need to remove moisture from dry products before coloring them. Lakes have also made possible the coloring of certain products that, because of their nature, method of preparation, or method of storage, caimot be colored with ordinary color additives. 

Fine chemicals There are many applications of the austenitic steels in the manufacture and storage of fine chemicals and pharmaceutical products. These include storage tanks, pipelines, valves, stills, steam-jacketed pans, mixing vessels, filters and tableting machinery. Considerable use has been made of these steels in penicillin production. 

Storage in the same primary container as will be used on the market, e.g., blister strips for tablets or ovules, tubes for creams, or vials and ampules for injectables. 

Fig. 18.2 Fungal growth on a tablet which has become damp (raised Aw) during storage under humid conditions. Note the sparseness of mycelium, and conidiophores. The contaminant is thought to be a Penicillium sp... 

Several all-in-one tablet testers are currently available that measure weight, thickness, diameter, and hardness of tablets. In addition these instruments provide digital storage and calculation of statistical parameters and allow for rapid feedback during the tableting process so that the tableting equipment can be adjusted accordingly with minimal downtime. ... 

The mechanical properties of materials, though not often studied in detail, can have a profound effect on solids processing. Clearly, tableting properties are influenced by the elastic and plastic deformation properties as well as the viscoelastic properties of a material. As we have pointed out, the powder flow properties are also affected, as well as the tendency of materials to set up on storage. Because of the importance of mechanical properties, it is important to be able to... 

Heavy-duty detergent tablets for textile laundry, as mentioned in chapter 4.2.4, use the presence of water to activate a sophisticated disintegration system that dispenses the tablets in a few seconds even though these products have to be stable and hard during storage and application [90, 91, 92]. These two systems are discussed in more detail in the following sections. 

The dissolution method for the immediate-release/sustained-release tablet requires the following parameters USP paddle method, 900 ml of water, SO rpm paddle speed, 37°C, and samphng points at 20 minutes, 40 minutes, 1, 2, 4, 6, 8 and 10 hours. Robotically, ahquots (8 ml) were removed, filtered through a 10 jm polyethylene filter and transferred to the storage rack. The volume (8 ml) was replaced with heated media. The samples were assayed hy HPLC using the external standard method. 

The properties of tablets are also influenced by temperature and humidity fluctuations, e.g., during storage. Is it possible to select excipient compositions that minimize the effect of temperature and humidity fluctuations on the quality of tablets These questions are raised and treated in a small example in Chapter 2 and extensively in Chapter 8. 

THE USE OF A FACTORIAL DESIGN TO EVALUATE THE PHYSICAL STABILITY OF TABLETS AFTER STORAGE UNDER TROPICAL CONDITIONS... 

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