T-cell antigens

Immune Defense. Figure 3 Drugs involved in suppressing innate and adaptive immune response. Abbreviations mob monoclonal antibody, TCR T-cell antigen receptor, IL-2 interleukin-2, R receptor, CD cluster of differentiation. 

Class IIHLA molecules are expressed on the surface of antigen-presenting cells. They play a key role in presentation of processed linear peptide antigens of at least nine amino acids to T cells. Antigen is bound to the HLA antigen binding cleft formed by the a and 3 chains of the HLA class II molecule. This tri-molecular HLA-antigen complex binds in turn to the variable portion of the T-cell receptor. 

T Cell Anergy T Cell Antigen Receptor T Cell Receptors T-cells... 

THP-1 Human monocytic leukaemia Thy 1+ Murine T cell antigen t.i.d. Ter in die (three times a day) TIL Tumour-infiltrating lymphocytes UMP Tissue inhibitors of metalloproteinase... 

Posnett, D.N., McGrath, H., and Tam, J.P. (1988) A novel method for producing anti-peptide antibodies Production of site-specific antibodies to the T-cell antigen receptor b-chain. J. Biol. Chem. 263, 1719-1725. 

T-cell antigen receptors belong to a separate family, which is composed of eight noncovalently bound trans-membrane subunits. The central ligand-binding element is a disulfide linked a,/1-heterodimer linked to the membrane by a short transmembrane sequence. The dimeric, variable subunits are the cellular equi-... 

Snodgrass, H.R., et al. Ontogeny of the T-cell antigen receptor within the thymus, Nature, 313, 592, 1985. 

Cl. Christmas, S. E., Cytokine production by T lymphocytes bearing the gamma delta T cell antigen receptor. Chem. Immunol. 53, 32-40 (1992). 

DE (TRAP) (T CELL ANTIGEN GP39) (CD154 ANTIGEN). 

A. M. Activation-dependent ubiqui-tination of a T cell antigen receptor subunit on multiple intracellular lysines. J. Biol. Chem., 1994, 269, 14244-14247. 

Keywords C otoxic T lymphocytes T cell antigen receptor allogeneic hemopoietic stem cell transplantation acnte myeloid lenkemia... 

Figure 1. Shaping the T cell repertoire in hemopoetic stem cell transplantation and immnno-therapy of malignant disease by T cell antigen receptor transfer.

Delivery of transgenic mice-derived T cell antigen receptors into human T lymphocytes. 

Primary antibody response to a T-cell antigen (if not already provided)... 

Donovan, J. A., R. L. Wange, W. Y. Langdon, and L. E. Samelson. The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol. Chem. 269 22921-22924.1994. 

Carrano AC, E an E, Hershko A, Pagano M (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nature Cell Biol 1 193-199 Cendarelli C, Hou D, Hsu KC, Rellahan BL, Wiest DL, Smith HT, Fried VA, Weissman AM 0992) Activation-induced ubiquitination of the T cell antigen receptor. Science 257 795-797... 

Huppa JB, Ploegh HL (1997) The a chain of the T cell antigen receptor is degraded in the cytosol. Immunity 7 113-122... 

Yu H, Kopito RR (1999) The role of multiubiquitination in dislocation and degradation of the a subunit of the T cell antigen receptor. J Biol Chem 274 36852-36858 Yuk MH, Lodish HF (1993) Two pathways for the degradation of the H2 subunit of the asialoglycoprotein receptor in the endoplasmic reticulum. ) Cell Biol 123 1735-1749... 

Kilmartin et al. (2006) 7 CD subjects Immune response of gliadin-reactive mucosal T cell lines to wheat, barley, rye, and oat-related cereals All 5 T cell lines demonstrated immunoreactivity to protein fractions from 4 related cereals Some cell lines reactivity to wheat, barley, and rye was evident only when cereal fractions were pretreated with tTG Confirms similar T cell antigenic reactivity of 4 related cereals... 

Qian, D. and Weiss, A. T cell antigen receptor signal transduction (1997) Curr. Op. Cell Biol. 9, 205- 212... 

Mueller, D. L., Jenkins, M. K., and Schwartz, R. H. (1989). Clonal expansion ver.sus functional clonal inactivation A costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7, 445-480. 

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