Anti-HIV peptides

Nishiyama, Y., Murakami, T., Kurita, K., Yamamoto, N., 1999. Low-molecular weight anti-HIV peptides for the amino-terminal sequence of RANTES possible lead compounds for coreceptor-directed anti-HIV agents. Bioorg. Med. Chem. Lett. 9, 1357-1360. 

Liu S, Jing W, Cheung B et al (2007) HIV gp41 C-terminal heptad repeat contains multifunctional domains. Relation to mechanisms of action of anti-HIV peptides. J Biol Chem 282 9612-9620... 

Fuzeon (enfuvirtide) is an anti-HIV drug. It interferes with the entry of HIV into the CD4 cell. It is a synthetic peptide with 36 amino acids, the N terminus is acetylated while the C terminal forms a carboxamide. The peptide binds to the gp41 subunit of the HIV envelope glycoprotein and prevents the HIV from fusing with CD4. 

Vangelista L, Longhi R, Sironi F et al (2006) Critical role of the N-loop and betal-strand hydrophobic clusters of RANTES-derived peptides in anti-HIV activity. Biochem Biophys Res Commun 351 664-668... 

Lusso P, Vangelista L, Cimbro R et al (2011) Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity. FASEB J 25 1230-1243... 

In collaboration with University of Trieste, we have developed rational approaches for the design and synthesis of peptidomimetic and non-peptidic inhibitors of HIV PR, utilizing structure-based [12-15], as well as combinatorial, library design methods [16, 17]. In this paper, we survey computer-assisted studies on the design, focusing and in silico screening of virtual combinatorial libraries of peptidomimetics and cyclic ureas, as potential anti-HIV agents, that were carried out in our laboratory. 

Anti-HIV compounds from marine sources also included terpenoids, steroids, peptides and alkaloids. Avarol, Fig. (1) and avarone. Fig. (2), sesquiterpenoid hydroquinones from the marine sponge Dysidea cinerea, are promising anti-HIV compounds [41,42]. Three new... 

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