Systemic sclerosis interstitial pneumonia

Fig. 26.27. Axial CT image in a patient with progressive systemic sclerosis shows a mixture of fine reticular and ground-glass opacities (black arrows), associated with mild traction bronchiectasis (white arrow), consistent with a nonspecific interstitial pneumonia pattern. Note esophageal dilatation (arrowheads)...

Figure 3 HRCT demonstrating classic UIP features including marked honeycomb changes with a subpleural and bibasilar predilection in a patient with systemic sclerosis. Abbreviations HRCT, high-resolution computed tomography UIP, usual interstitial pneumonia.

Abbreviations-. ILA, interstitial lung disease RA, rheumatoid arthritis SLE, systemic lupus erythematosus SSc, systemic sclerosis DM, dermatomyositis PM, polymyositis SjS, Sjogren s syndrome MCTD, mixed connective tissue disease NSIP, non-specific interstitial pneumonia UIP, usual interstitial pneumonia OP, organizing pneumonia DAD, diffuse alveolar damage DIP, desquamative interstitial pneumonia LIP, lymphocytic interstitial pneumonia. 

Figure 1 Typical pattern of mixed nonspecific interstitial pneumonia in a patient with systemic sclerosis. The interstitium is infiltrated by lymphocytes. Fibrosis is present but mild with temporal homogeneity. Fibroblastic foci are absent. Note the presence of lymphoid follicles arrow). HES 20x.

Figure 2 (A) and (B) HRCT appearances in a patient with systemic sclerosis, showing a pattern suggestive of nonspecific interstitial pneumonia in association with esophageal dilatation and pericardial thickening.

Meloni F, Caporali R, Marone Bianco A, et al. Cytokine profile of bronchoalveolar lavage in systemic sclerosis with interstitial lung disease comparison with usual interstitial pneumonia. Ann Rheum Dis 2004 63 892-894. 

Fujita J, Yoshinouchi T, Ohtsuki Y, et al. Non-specific interstitial pneumonia as pulmonary involvement of systemic sclerosis. Ann Rheum Dis 2001 60 281-283. 

Desai SR, Veeraraghavan S, Hansell DM, et al. CT features of lung disease in patients with systemic sclerosis comparison with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. Radiology 2004 232 560-567. 

Kim EA, Johkoh T, Lee KS, et al. Interstitial pneumonia in progressive systemic sclerosis serial high-resolution CT findings with functional correlation. J Comput Assist Tomogr 2001 25 757-763. 

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