Non-specific interstitial pneumonia

A 33-year-old man taking co-trimoxazole developed bilateral pulmonary infiltrates and a fever of 39 C after 2 weeks (25). Co-trimoxazole was withdrawn. The fever resolved 6 days later. A lung biopsy showed non-specific interstitial pneumonia. A lymphocyte stimulation test for co-trimoxazole was positive. 

Coche E, Weynand B, Noirhomme P, et al. Non-specific interstitial pneumonia showing a crazy paving pattern on high resolution CT. Br J Radiol 2001 74(878) 189 191. 

Fujita J, Yamadori I, Suemitsu 1, et al. Clinical features of non-specific interstitial pneumonia. Respir Med 1999 93 113-118. 

Abbreviations-. ILA, interstitial lung disease RA, rheumatoid arthritis SLE, systemic lupus erythematosus SSc, systemic sclerosis DM, dermatomyositis PM, polymyositis SjS, Sjogren s syndrome MCTD, mixed connective tissue disease NSIP, non-specific interstitial pneumonia UIP, usual interstitial pneumonia OP, organizing pneumonia DAD, diffuse alveolar damage DIP, desquamative interstitial pneumonia LIP, lymphocytic interstitial pneumonia. 

Fujita J, Ohtsuki Y, Yoshinouchi T, et al. Idiopathic non-specific interstitial pneumonia as an autoimmune interstitial pneumonia . Respir Med 2005 99 234-240. 

Fujita J, Yoshinouchi T, Ohtsuki Y, et al. Non-specific interstitial pneumonia as pulmonary involvement of systemic sclerosis. Ann Rheum Dis 2001 60 281-283. 

Atkins SR, Matteson EL, Myers JL, et al. Morphological and quantitative assessment of mast cells in rheumatoid arthritis associated non-specific interstitial pneumonia and usual interstitial pneumonia. Ann Rheum Dis 2006 65 677-680. 

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