Syndromes cerebral palsy

It is indicated in spasticity due to neurological disorders e.g., multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord, cerebrovascular accidents and cerebral palsy painful muscle spasm associated with static and functional disorders of the spine (cervical and lumbar syndromes) painful muscle spasm following surgery e.g., for herniated intervertebral disc or for osteoarthritis of the hip. 

Methylmercury intoxication affects mainly the central nervous system and results in paresthesias, ataxia, hearing impairment, dysarthria, and progressive constriction of the visual fields. Signs and symptoms of methylmercury intoxication may first appear several weeks or months after exposure begins. Methylmercury is a reproductive toxin. High-dose prenatal exposure to methylmercury may produce mental retardation and a cerebral palsy-like syndrome in the offspring. Low-level prenatal exposures to methylmercury have been associated with a risk of subclinical neurodevelopmental deficits. 

I.6. Various Diseases. Abbassy et al. (Al) observed in 12 cases of malnutrition (including kwashiorkor), toxic dyspepsia, 8 cases of acute nephritis, 8 cases of infective hepatitis, and muscular dystrophy an increased spontaneous excretion of xanthurenic acid, the amount of which was found to depend on the severity of the case. In all these cases, with the exception of acute nephritis and hepatitis, the amount of xanthurenic acid was restored to normal levels after vitamin Be therapy. In 8 children with mental retardation, cerebral palsy, recurrent convulsions, 5 with nephrotic syndrome, and 5 with pellagra the amount of xanthurenic acid spontaneously excreted was found to be within the normal range, indicating that pyridoxine is probably not concerned in these cases. 

A common feature of brain damage between early gestation and infancy is destruction of this cerebral white matter, the fiber tracts that connect one part of the brain to other parts or to the spinal cord. A common consequence of large-scale white matter damage is a clinical syndrome in which disturbances of motor control are prominent. Cerebral palsy is such a syndrome. 

Benzodiazepines are of value in alleviating the symptoms of cerebral palsy, spasticity resulting from degenerative disorders such as multiple sclerosis, tetanus, stiff-man syndrome, and backache and muscle strain. The effective doses are generally large and may be increased as the disease progresses (e.g., multiple sclerosis). 

Methylmercury is a potent reproductive toxin, and perinatal exposure has caused mental retardation and a cerebral palsy-type syndrome in offspring. 

The different functions of the BPB (as a stimulator, biopotential signal sensor, goniometry sensor, and pressure or temperature sensor) and the availability of multiple BPBs in one patient (up to 850 BPBs) gives the cUnidan many opportunities to restore neurological function, espedaUy in poststroke syndrome, spinal cord injury, cerebral palsy, multiple sclerosis, traumatic brain injury, and for limb sensing in amputees to control fitted prostheses. 

Perry D, Birthi P, Salles S, McDowell S. Neuroleptic malignant syndrome associated with the use of cartridopa/levodopa for dystonia in persons with cerebral palsy. PM R 2012 4(5) 383-4. 

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