Survive adenomas

No decrease in survival 20% of females developed adrenal cortical adenomas and 10% had neoplastic nodules in the adrenal cortex vs. 0% in controls... 

No decrease in survival. Increased frequency of adrenal cortex adenomas in females 25% vs. 1.3% in controls... 

In chronic inhalation studies rats and mice were exposed to 0, 75, 250, or 750ppm 6 hours/day, 5 days/week for 104 weeks. Eor male rats exposed at 750 ppm survival was decreased, and the incidence of renal tubule neoplasms and testicular adenomas was increased. The findings from an extended evaluation of the kidneys showed a significant increase in the incidences of renal tubule adenoma and hyperplasia in high-dose males and females. In high-dose mice there were increased incidences of alveolar/bronchiolar neoplasms in males, whereas females had... 

No excess of cancer was reported in two follow-up smdies of affected individuals in Turkey about 20-30 years after consumption of contaminated grain had ceased. " In mice, liver tumors were observed after exposure to HCB at 12-24mg/kg/day in the diet, but not at 6mg/kg/day. Hepatomas, hepatocellular carcinomas, bile duct adenomas, and renal cell adenomas were observed in rats after dietary administration." Liver tumors were also observed in 100% of surviving females and 16% of males after dietary administration to rats for 90 weeks. In another study, increased incidence of parathyroid adenomas and adrenal pheochromocytomas were observed in male and female rats and liver neoplastic nodules in females of the Ei generation in a two-generation feeding study. 

Mice were administered 250 or 500mg/ kg/day pentachloroethane by gavage for life. The hepatic carcinogenicity of pentachloroethane was clearly established despite reduced survival rates. The incidence of hepatocellular carcinomas was significantly increased in low-dose males and in treated females there also was a significant dose-related increase in the incidence of hepatocellular adenomas in treated females. ... 

No degenerative changes in the pulmonary parenchyma were found, but 7/20 mice that died 15 months after intravenous injection of Thorotrast (Guimaraes et al. 1955) and 8/20 mice that were sacrificed 5-12 months after injection of Thorotrast (Guimaraes and Lamerton 1956) had lung adenomas. There was no significant difference in survival between the treated and control animals in either study. In a few cases, an association between the presence of Thorotrast deposits in the lungs and the proliferation of bronchioles and alveoli was found. 

---