Suppositories dosage form

Schedule II barbiturates in mixtures with noncontrolled drugs or in suppository dosage form... 

In the case of suppository dosage forms, a greater amount of K-carrageenan is required in the presence of potassium to form a more rigid structure. 

Murrukmihadi M. Effect of cera flava on the release of sodium salicylate from suppository dosage form. Indonesian ] Pharm 1999 10(3) 135-139. 

Hydromorphone Hydrochloride, U5P. Hydromor-phone hydrochloride, dibydromurphinonc hydrochloride (Dilaudid). (K-curs as a light-sensitive, while cry.sialline powder that is freely soluble in water (l .1).. sparingly soluble in alcohol, and practically insoluble in ether. It is used in about one-fifth die dose of morphine for any of the indications of morphine. It is available in tablet, liquid, parenteral, and suppository dosage forms. The dose is I to 8 mg. 

A suppository dosage form is widely used for administration of drugs having irritative character or that suffer decomposition in the first pass process by the liver. Two types of suppository base materials are applied, hydrophilic and lipophilic types. The wetting... 

Rectal Administration. The administration of drugs by a solid rectal dosage form (i.e., suppositories) results in a wide variability in the rate and extent of absorption in children [79]. This fact, coupled with the inflexibility of a fixed dose, makes this a route that should not be promoted for pediatric patients. At least one death involving a 7-month-old infant can be directly attributed to the use of solid rectal dosage form of a therapeutic dose of morphine [80]. 

Solid oral dosage forms, particularly tablets, are the preferred type of formulation in the United States. Not only are these products widely accepted by consumers, but they are also relatively cheaper to develop and manufacture than oral liquids or suspensions, par-enterals, or suppositories. Figure 4 shows, quite clearly, that even the elderly primarily make use of solid oral dosage forms [162]. 

More elaborate sample preparation is often needed for complex sample matrices, e.g., lotions and creams. Many newer SP technologies such as solid-phase extraction (SPE), supercritical fluid extraction (SFE), pressurized fluid extraction, accelerated solvent extraction (ASE), and robotics are frequently utilized (see Ref. [2]). Dosage forms such as suppositories, lotions, or creams containing a preponderance of hydrophobic matrices might require more elaborate SP and sample cleanup, such as SPE or liquid-liquid extraction. 

The standard temperature for the dissolution medium is 37 0.5°C for oral dosage forms. Slightly increased temperatures such as 38 0.5°C have been recommended for dosages forms such as suppositories. Lower temperatures such as 32 0.5°C are utilized for topical dosage forms such as trans-dermal patches and topical ointments. 

The pharmaeeutieal industry began to take over the produetion of most medications used by the medieal profession. In many ways this has provided superior service, new methods, and a vast array of innovative products that could not have been provided in a one-on-one situation. Research and development have been the hallmarks of the pharmaeeutieal manufaeturers. However, the very nature of providing millions of doses of a produet requires that the dosage forms (capsule, tablet, suppository) and doses (individual strengths of eaeh dose) be limited and results in a one-sided approach to therapy. It is simply not eeonomical for a pharmaeeutieal eompany to produce a produet in 50 different eoneeivable doses, or 15 different dosage forms, to meet the needs of the entire range of patients reeeiving therapy. Windows of activity are determined whieh meet most patient needs, but the very nature of the process is not able to meet all patient needs. 

Suppositories are solid dosage forms that are used to administer medieine through the rectum, vagina, or urethra. They are of different sizes or shapes, depending upon... 

The inclusion of the a routine microbial limit test in a marketed product stability protocol depends on the pharmaceutical dosage form. Typically, the test would be used only for nonsterile products, especially oral liquids, nasal sprays, and topical liquids, lotions, and creams that have sufficient water activity to support the growth of microorganisms. In contrast, tablets, powder- and liquid-filled capsules, topical ointments, vaginal and rectal suppositories, nonaqueous liquids and inhalation aerosols with a water activity too low to allow for the product to support the growth of microorganisms would not be routinely tested. 

Paracetamol suppositories may have been preferred to the oral dosage form, either because the patient is reluctant to take the medication or because the patient is vomiting. 

Absorption - Theophy ne is well absorbed from oral liquids and uncoated plain tablets maximal plasma concentrations are reached in 2 hours. Rectal absorption from suppositories is slow and erratic, the oral route is generally preferred. Enteric-coated tablets and some sustained-release dosage forms may be unreliably absorbed. 

Non-aqueous titration methods have been described for the rapid determination of chlorpromazine and its hydrochloride salt by titration with perchloric acid [54]. The titration is performed after the proscribed extraction from suppository, tablet, and ampoule dosage forms is completed. 

Drugs are administrated by intravenous routes or ex-travascular routes including oral, sublingual, subcutaneous, intramuscular, rectal (by enema or suppository), and transdermal. Available dosage forms include suspensions, immediate-release capsules or tablets, sustained-release capsules or tablets, and enteric-coated capsules or tablets that resist dissolution in the acidic pfi of the stomach. 

Solid dosage form includes capsules, granules, effervescent granules, powders, tablets, insufflations, suppositories (pessaries, bougies and ear cone) etc. 

Suppositories are pharmaceutical dosage forms intended for administration of medicine via the rectum, vagina, or urethra that melt, soften, or dissolve in the body cavity. Rectal and vaginal suppositories are most common but urethral suppositories are sometimes used. Suppositories are indicated for administering drugs to infants and small children, severely debilitated patients, those who cannot take medications orally, and those for whom the parenteral route might be unsuitable. Suppositories are used to administer drugs for either systemic or local application. Local applications include the... 

Suppositories and inserts. In Ansel H, Allen L Jr, Popovich N, eds. Pharmaceutcial Dosage Forms and Drug Delivery Systems. 7th ed. Lippincott Williams and Wilkins, 1999. 

A change in the container closure system of unit dose packaging (e.g., blister packs) for nonsterile solid dosage fonn products, as long as the new package provides the same or better protective properties and any new primary packaging component materials have been used in and been in contact with CDER-approved products of the same type (e.g., solid oral dosage form, rectal suppository). 

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