Sulforaphane carcinogenesis

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Fimognari, C., Nusse, M., Cesari, R., lori, R., Cantelli-Forti, G., and Hreha, P. Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis, 23, 581-586, 2002. 

CHUNG F L, CONAWAY c c, RAO c V and REDDY B s (2000) Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate . Carcinogenesis, 21 2287-91. 

Singh AV, Xiao D, Lew KL, Dhir R, Singh SV. (2004) Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis 25 83-90. 

Chemoprevention is a strategy used to block or suppress carcinogenesis and degenerative disease using dietary or pharmacological compounds. These chemo-preventive compounds include phenols [such as tm-butyl 4-hydroxyanisole (BHA), t-BHQ (active metabolite of BHA), ethoxyquine, curcumin (from turmeric) and resveratrol (from grapes)] and sulfur compounds [such as oltiplaz, sulforaphane... 

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Zhang JS, Svehlikova V, Bao YP, Howie AF, Beckett GJ, Williamson G. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 2003 24 497-503. 

Comblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen MS, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K (2007) Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis 28 1485-1490... 

Comblatt, B.S. et al. (2007) Preclinical and clinical evaluation of sulforaphane for chemo-prevention in the breast. Carcinogenesis 28 1485-1490... 

Basten, G.P., Bao, Y. and Williamson, G. (2002) Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGTIAI) and glutathione transferase (GSTAl) in cultured cells. Carcinogenesis, 23, 1399-1404. 

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